Effects of sugar cane extract on pseudorabies virus challenge of pigs

L. O. Dan-Yuan, Maw Sheng Chien, Kuang Sheng Yeh, Kenji Koge, Cheng Chung Lin, Shih Ling Hsuan, Wei Cheng Lee

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5 Citations (Scopus)

Abstract

This experiment aimed to evaluate the efficacy of sugar cane extract (SCE) on the modulation of porcine immunity against pseudorabies virus (PrV) infection. Twelve-week-old experimental pigs were fed with SCE (500 mg/kg of body weight per day) for 3 days and challenged with PrV (2 × 10 5 TCID50) on the second day. Pigs that were only challenged with PrV and without SCE-treatment served as controls. The leukocyte functional assays were performed on the 7th and 14th day post-PrV challenge. Our results showed a significant enhancement (P4+ and γδ T cells in the SCE-treated pigs compared with the controls. In addition, SCE administration reduced the severity of clinical signs and brain lesion in the course of disease in PrV-challenged pigs. SCE-treated pigs showed a 12% growth enhancement compared with untreated controls. SCE administration had an immunostimulating effect on porcine immunity that may subsequently enhance protective activities against PrV infection which may be extensively applied in field for the prevention of infections.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalJournal of Veterinary Medical Science
Volume68
Issue number3
DOIs
Publication statusPublished - Mar 2006

Keywords

  • Immunomodulation
  • Interferon-gamma
  • Leukocyte function
  • Pseudorabies
  • Sugar cane extract

ASJC Scopus subject areas

  • veterinary(all)
  • Marketing

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  • Cite this

    Dan-Yuan, L. O., Chien, M. S., Yeh, K. S., Koge, K., Lin, C. C., Hsuan, S. L., & Lee, W. C. (2006). Effects of sugar cane extract on pseudorabies virus challenge of pigs. Journal of Veterinary Medical Science, 68(3), 219-225. https://doi.org/10.1292/jvms.68.219