Effects of statins on incident dementia in patients with type 2 DM: A population-based retrospective cohort study in Taiwan

Jui Ming Chen, Cheng Wei Chang, Tzu Hao Chang, Chi Chang Hsu, Jorng Tzong Horng, Wayne H H Sheu

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Background: Patients with Type 2 diabetes (T2DM) are prone to develop dementia. Results from a recent study indicated that statin users had lower chance of developing incident dementia. However there is little information on the potential benefits of statin use on dementia in patients with T2DM cohort. Method: A population-based retrospective study using a nationwide cohort of National Health Insurance Research Database in Taiwan was performed. T2DM cohort with regular use of statins was followed up to 8 years. Multivariate cox-proportional hazards regression model was used to estimate the association between statin use and incidence of dementia including Alzheimer's disease and non-Alzheimer dementia after adjusting for several potential confounders. Results: Among 28,321 patients diagnosed with T2DM age above 50 and without history of dementia before 2000/1/1, 15,770 patients who had never used statin and 2,400 patients who regularly used statin drugs were enrolled. After adjusting for age group, gender, CCI (Charlson-Deyo comorbidity index) group, stroke types and anti-diabetic drugs, regular statin use was associated with a decreased risk of developing incident Alzheimer's disease dementia (adjusted HR: 0.48, 95% CI 0.30-0.76, p

Original languageEnglish
Article numbere88434
JournalPLoS One
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 10 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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