Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats

A. Noda, T. Sendo, K. Ohno, S. Goto, H. Noda, K. Y. Hsu

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12 Citations (Scopus)

Abstract

After the intraperitoneal (i.p.) administration of isoniazid (INH) to male Wistar rats, the liver and plasma levels of hydrazine (Hz) and acetylhydrazine (AcHz), which are hazardous metabolites of INH and well known as mutagens, carcinogens and hepatotoxins, were determined by gas chromatographymass spectrometry (GC-MS). The levels of Hz in rifampicin (RMP)- or phenobarbital (PB)-pretreated groups were lower than those in the control group, while the amount of AcHz was scarcely altered. In each of the pretreated groups a pronounced increase in the oxidative elimination rate of Hz was observed. These results are of important toxicological significance in INH therapy with RMP, since an active intermediate of Hz seems to be a hepatotoxin.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalToxicology Letters
Volume25
Issue number3
DOIs
Publication statusPublished - 1985

Keywords

  • Hydrazine
  • liver
  • mass fragmentography
  • plasma
  • urine

ASJC Scopus subject areas

  • Toxicology

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