Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins

Implication in initiation of atrial fibrillation

Yi J. Chen, Shih A. Chen, Yao Chang Chen, Hung I. Yeh, Paul Chan, Mau Song Chang, Cheng I. Lin

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

Background - Pulmonary veins (PVs) are important sources of paroxysmal atrial fibrillation. Long-term rapid atrial pacing (RAP) changes atrial electrophysiology and facilitates the maintenance of atrial fibrillation. It is not clear whether RAP alters the arrhythmogenic activity of PVs. The purpose of this study was to isolate single PV cardiomyocytes from control and RAP dogs and evaluate their electrophysiological characteristics. Methods and Results - The action potential and ionic currents were investigated in PV cardiomyocytes from control and long-term (6 to 8 weeks) RAP (780 bpm) dogs by use of the whole-cell clamp technique. Dissociation of PVs yielded rod-shaped single cardiomyocytes without (n=91, 60%) or with (n=60, 40%) pacemaker activity. Compared with the control group, the RAP dog PV cardiomyocytes had faster beating rates (0.86±0.28 versus 0.45±0.07 Hz, P

Original languageEnglish
Pages (from-to)2849-2854
Number of pages6
JournalCirculation
Volume104
Issue number23
Publication statusPublished - Dec 4 2001
Externally publishedYes

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Pulmonary Veins
Cardiac Myocytes
Atrial Fibrillation
Dogs
Electrophysiology
Action Potentials
Maintenance
Control Groups

Keywords

  • Action potentials
  • Fibrillation
  • Ion channels
  • Lung
  • Pacing
  • Veins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins : Implication in initiation of atrial fibrillation. / Chen, Yi J.; Chen, Shih A.; Chen, Yao Chang; Yeh, Hung I.; Chan, Paul; Chang, Mau Song; Lin, Cheng I.

In: Circulation, Vol. 104, No. 23, 04.12.2001, p. 2849-2854.

Research output: Contribution to journalArticle

Chen, Yi J. ; Chen, Shih A. ; Chen, Yao Chang ; Yeh, Hung I. ; Chan, Paul ; Chang, Mau Song ; Lin, Cheng I. / Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins : Implication in initiation of atrial fibrillation. In: Circulation. 2001 ; Vol. 104, No. 23. pp. 2849-2854.
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AU - Yeh, Hung I.

AU - Chan, Paul

AU - Chang, Mau Song

AU - Lin, Cheng I.

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