Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults

A systematic review and meta-analysis

Chun De Liao, Jau Yih Tsauo, Yen Tzu Wu, Chin Pao Cheng, Hui Chuen Chen, Yi Ching Huang, Hung Chou Chen, Tsan Hon Liou

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background: Overweight and obese older people face a high risk of muscle loss and impaired physical function, which may contribute to sarcopenic obesity. Resistance exercise training (RET) has a beneficial effect on muscle protein synthesis and can be augmented by protein supplementation (PS). However, whether body weight affects the augmentation of muscular and functional performance in response to PS in older people undergoing RET remains unclear. Objective: This study was conducted to identify the effects of PS on the body composition and physical function of older people undergoing RET. Design: We performed a comprehensive search of online databases to identify randomized controlled trials (RCTs) reporting the efficacy of PS for lean mass gain, strength gain, and physical mobility improvements in older people undergoing RET. Results: We included 17 RCTs; the overall mean 6 SD age and body mass index (BMI; in kg/m2) in these RCTs were 73.4 6 8.1 y and 29.7 6 5.5, respectively. The participants had substantially greater lean mass and leg strength gains when PS and RET were used than with RET alone, with the standard mean differences (SMDs) being 0.58 (95% CI: 0.32, 0.84) and 0.69 (95% CI: 0.39, 0.98), respectively. The subgroup of studies with a mean BMI $30 exhibited substantially greater lean mass (SMD: 0.53; 95% CI: 0.19, 0.87) and leg strength (SMD: 0.88; 95% CI: 0.42, 1.34) gains in response to PS. The subgroup of studies with a mean BMI,30 also exhibited relevant gains in response to PS. Conclusions: Compared with RET alone, PS combined with RET may have a stronger effect in preventing aging-related muscle mass attenuation and leg strength loss in older people, which was found in studies with a mean BMI $30 and in studies with a mean BMI,30. Clinicians could use nutrition supplement and exercise strategies, especially PS plus RET, to effectively improve the physical activity and health status of all older patients.

Original languageEnglish
Pages (from-to)1078-1091
Number of pages14
JournalAmerican Journal of Clinical Nutrition
Volume106
Issue number4
DOIs
Publication statusPublished - Oct 1 2017

Fingerprint

Body Composition
Resistance Training
Meta-Analysis
Exercise
Proteins
Leg
Randomized Controlled Trials
Muscles
Muscle Proteins
Health Status
Body Mass Index
Obesity
Body Weight
Databases

Keywords

  • Body composition
  • Elderly people
  • Obesity
  • Protein supplementation
  • Resistance exercise

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of protein supplementation combined with resistance exercise on body composition and physical function in older adults : A systematic review and meta-analysis. / Liao, Chun De; Tsauo, Jau Yih; Wu, Yen Tzu; Cheng, Chin Pao; Chen, Hui Chuen; Huang, Yi Ching; Chen, Hung Chou; Liou, Tsan Hon.

In: American Journal of Clinical Nutrition, Vol. 106, No. 4, 01.10.2017, p. 1078-1091.

Research output: Contribution to journalArticle

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abstract = "Background: Overweight and obese older people face a high risk of muscle loss and impaired physical function, which may contribute to sarcopenic obesity. Resistance exercise training (RET) has a beneficial effect on muscle protein synthesis and can be augmented by protein supplementation (PS). However, whether body weight affects the augmentation of muscular and functional performance in response to PS in older people undergoing RET remains unclear. Objective: This study was conducted to identify the effects of PS on the body composition and physical function of older people undergoing RET. Design: We performed a comprehensive search of online databases to identify randomized controlled trials (RCTs) reporting the efficacy of PS for lean mass gain, strength gain, and physical mobility improvements in older people undergoing RET. Results: We included 17 RCTs; the overall mean 6 SD age and body mass index (BMI; in kg/m2) in these RCTs were 73.4 6 8.1 y and 29.7 6 5.5, respectively. The participants had substantially greater lean mass and leg strength gains when PS and RET were used than with RET alone, with the standard mean differences (SMDs) being 0.58 (95{\%} CI: 0.32, 0.84) and 0.69 (95{\%} CI: 0.39, 0.98), respectively. The subgroup of studies with a mean BMI $30 exhibited substantially greater lean mass (SMD: 0.53; 95{\%} CI: 0.19, 0.87) and leg strength (SMD: 0.88; 95{\%} CI: 0.42, 1.34) gains in response to PS. The subgroup of studies with a mean BMI,30 also exhibited relevant gains in response to PS. Conclusions: Compared with RET alone, PS combined with RET may have a stronger effect in preventing aging-related muscle mass attenuation and leg strength loss in older people, which was found in studies with a mean BMI $30 and in studies with a mean BMI,30. Clinicians could use nutrition supplement and exercise strategies, especially PS plus RET, to effectively improve the physical activity and health status of all older patients.",
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AU - Liao, Chun De

AU - Tsauo, Jau Yih

AU - Wu, Yen Tzu

AU - Cheng, Chin Pao

AU - Chen, Hui Chuen

AU - Huang, Yi Ching

AU - Chen, Hung Chou

AU - Liou, Tsan Hon

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