Effects of protein supplementation combined with exercise training on muscle mass and function in older adults with lower-extremity osteoarthritis: A systematic review and meta-analysis of randomized trials

Chun De Liao, Yen Tzu Wu, Jau Yih Tsauo, Pey Rong Chen, Yu Kang Tu, Hung Chou Chen, Tsan Hon Liou

Research output: Contribution to journalReview article

Abstract

Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement.

Original languageEnglish
Article number2422
Pages (from-to)1-19
Number of pages19
JournalNutrients
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Arthroplasty
  • Exercise training
  • Muscle mass
  • Osteoarthritis
  • Physical function
  • Protein supplement
  • Sarcopenia

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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