Abstract

Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p

Original languageEnglish
Pages (from-to)9274-9279
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number19
DOIs
Publication statusPublished - 2009

Fingerprint

Dioscorea
Cytophagocytosis
yams
natural killer cells
storage proteins
splenocytes
phagocytosis
Natural Killer Cells
oral administration
Oral Administration
mouth
tubers
Cells
immune response
Peyer's Patches
Peyer's patches
Lymphocytes
Macrophages
Lymphocyte Subsets
mice

Keywords

  • Dioscorin
  • Immunomodulatory
  • Mucosal
  • Yam

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses. / Liu, Yen Wenn; Liu, J. U Chi; Huang, Chun Yao; Wang, Chung Kwe; Shang, Huey Fang; Hou, Wen Chi.

In: Journal of Agricultural and Food Chemistry, Vol. 57, No. 19, 2009, p. 9274-9279.

Research output: Contribution to journalArticle

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AU - Liu, J. U Chi

AU - Huang, Chun Yao

AU - Wang, Chung Kwe

AU - Shang, Huey Fang

AU - Hou, Wen Chi

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