19 Citations (Scopus)

Abstract

The tyrosinase inhibitory and antioxidant activities of four nicotinic acid derivatives, namely, nicotinamide, methyl nicotinate, nicotinic acid hydroxamate (NAH), N-methyl nicotinic acid hydroxamate (NAH-M), and kojic acid, were studied. The tyrosinase inhibitory activity was found to follow the trend: NAH > kojic acid > NAH-M > methyl nicotinate > nicotinamide. The concentrations of half-inhibition (IC 50) of NAH against monophenolase and diphenolase activity were 2 and 1 μM, respectively; the inhibition mode was a mixed-type in the former and an uncompetitive type in the latter. In the antioxidant activity assays, NAH and NAH-M, but not nicotinamide or methyl nicotinate, showed dose-dependent DPPH radical scavenging activity, and their corresponding IC 50 values were 65.81 and 125 μM, respectively. NAH and NAH-M also showed hydroxyl radical scavenging activity and anti-low-density-lipoprotein peroxidation. These results indicate that NAH and NAH-M have the potential to be useful in cosmetics or food processing, and therefore, they should be investigated further.

Original languageEnglish
Pages (from-to)2074-2080
Number of pages7
JournalFood Chemistry
Volume132
Issue number4
DOIs
Publication statusPublished - Jun 15 2012

Fingerprint

Monophenol Monooxygenase
Niacin
niacin
catechol oxidase
Antioxidants
antioxidant activity
chemical derivatives
Derivatives
nicotinamide
Niacinamide
kojic acid
Scavenging
inhibitory concentration 50
Food processing
Food Handling
Cosmetics
peroxidation
low density lipoprotein
hydroxyl radicals
cosmetics

Keywords

  • Antioxidant activity
  • Kojic acid
  • Nicotinic acid hydroxamate (NAH)
  • Tyrosinase

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry

Cite this

Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities. / Lin, Yin Shiou; Chen, Sheng-Hsuan; Huang, Wei Jan; Chen, Chao Hsiang; Chien, Mei Yin; Lin, Shyr Yi; Hou, Wen Chi.

In: Food Chemistry, Vol. 132, No. 4, 15.06.2012, p. 2074-2080.

Research output: Contribution to journalArticle

Lin, Yin Shiou ; Chen, Sheng-Hsuan ; Huang, Wei Jan ; Chen, Chao Hsiang ; Chien, Mei Yin ; Lin, Shyr Yi ; Hou, Wen Chi. / Effects of nicotinic acid derivatives on tyrosinase inhibitory and antioxidant activities. In: Food Chemistry. 2012 ; Vol. 132, No. 4. pp. 2074-2080.
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AU - Lin, Yin Shiou

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AU - Chien, Mei Yin

AU - Lin, Shyr Yi

AU - Hou, Wen Chi

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AB - The tyrosinase inhibitory and antioxidant activities of four nicotinic acid derivatives, namely, nicotinamide, methyl nicotinate, nicotinic acid hydroxamate (NAH), N-methyl nicotinic acid hydroxamate (NAH-M), and kojic acid, were studied. The tyrosinase inhibitory activity was found to follow the trend: NAH > kojic acid > NAH-M > methyl nicotinate > nicotinamide. The concentrations of half-inhibition (IC 50) of NAH against monophenolase and diphenolase activity were 2 and 1 μM, respectively; the inhibition mode was a mixed-type in the former and an uncompetitive type in the latter. In the antioxidant activity assays, NAH and NAH-M, but not nicotinamide or methyl nicotinate, showed dose-dependent DPPH radical scavenging activity, and their corresponding IC 50 values were 65.81 and 125 μM, respectively. NAH and NAH-M also showed hydroxyl radical scavenging activity and anti-low-density-lipoprotein peroxidation. These results indicate that NAH and NAH-M have the potential to be useful in cosmetics or food processing, and therefore, they should be investigated further.

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