Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition

Sung Ling Yeh, Ken Yu Chang, Po Chao Huang, Wei Jao Chen

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The effect of total parenteral nutrition (TPN) enriched with n-3 or n-6 fatty acids on the concentration of plasma eicosanoids was evaluated in rats. Rats were divided into three groups: the control group (n = 6) was fed a chow diet and infused with saline only. Two experimental groups (n = 11, 13) received TPN solutions at an energy level of 30 kcal/100 g body weight with 40% energy provided as fat. The experimental groups were maintained on TPN for a period of 7 d. The basal TPN solutions were isonitrogenous and identical in nutrient composition except for differences in lipid source. One experimental group received a safflower oil emulsion, whereas the other group received a fish oil emulsion. At the end of the experimental period, plasma 6-keto prostaglandin F(1α), thromboxane B2, bleeding time, lipid peroxidation products, and antioxidant enzymes of liver were analyzed. The results demonstrated that the fish oil group had lower 6-keto prostaglandin F(1α) concentration than the safflower oil group. Also, plasma thromboxane B2 was the lowest in the fish oil group among the three groups. There was no difference in bleeding time among the groups. With regard to liver lipid peroxidation products, malondialdehyde concentration was not higher in the fish oil group, whereas superoxide dismutase and glutathione peroxidase activities were lower in the fish oil group compared with the control and safflower oil groups. The results suggest that TPN prepared with fish oil fat emulsion causes less accumulation of lipid peroxidation products in the liver of rats, and may be beneficial in preventing platelet aggregation.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalNutrition
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 1997

Fingerprint

Eicosanoids
Fish Oils
Total Parenteral Nutrition
Fatty Acids
Antioxidants
Safflower Oil
Liver
Enzymes
Emulsions
Parenteral Nutrition Solutions
Lipid Peroxidation
Thromboxane B2
Bleeding Time
Prostaglandins F
Fats
Glutathione Peroxidase
Malondialdehyde
Platelet Aggregation
Superoxide Dismutase
Body Weight

Keywords

  • 6- keto prostaglandin F(1α)
  • fish oil emulsion
  • safflower oil emulsion
  • thromboxane B
  • total parenteral nutrition

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery
  • Medicine (miscellaneous)

Cite this

Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition. / Yeh, Sung Ling; Chang, Ken Yu; Huang, Po Chao; Chen, Wei Jao.

In: Nutrition, Vol. 13, No. 1, 01.1997, p. 32-36.

Research output: Contribution to journalArticle

Yeh, Sung Ling ; Chang, Ken Yu ; Huang, Po Chao ; Chen, Wei Jao. / Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition. In: Nutrition. 1997 ; Vol. 13, No. 1. pp. 32-36.
@article{0ecc05efa8eb46be9d34dc4fa5eb8199,
title = "Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition",
abstract = "The effect of total parenteral nutrition (TPN) enriched with n-3 or n-6 fatty acids on the concentration of plasma eicosanoids was evaluated in rats. Rats were divided into three groups: the control group (n = 6) was fed a chow diet and infused with saline only. Two experimental groups (n = 11, 13) received TPN solutions at an energy level of 30 kcal/100 g body weight with 40{\%} energy provided as fat. The experimental groups were maintained on TPN for a period of 7 d. The basal TPN solutions were isonitrogenous and identical in nutrient composition except for differences in lipid source. One experimental group received a safflower oil emulsion, whereas the other group received a fish oil emulsion. At the end of the experimental period, plasma 6-keto prostaglandin F(1α), thromboxane B2, bleeding time, lipid peroxidation products, and antioxidant enzymes of liver were analyzed. The results demonstrated that the fish oil group had lower 6-keto prostaglandin F(1α) concentration than the safflower oil group. Also, plasma thromboxane B2 was the lowest in the fish oil group among the three groups. There was no difference in bleeding time among the groups. With regard to liver lipid peroxidation products, malondialdehyde concentration was not higher in the fish oil group, whereas superoxide dismutase and glutathione peroxidase activities were lower in the fish oil group compared with the control and safflower oil groups. The results suggest that TPN prepared with fish oil fat emulsion causes less accumulation of lipid peroxidation products in the liver of rats, and may be beneficial in preventing platelet aggregation.",
keywords = "6- keto prostaglandin F(1α), fish oil emulsion, safflower oil emulsion, thromboxane B, total parenteral nutrition",
author = "Yeh, {Sung Ling} and Chang, {Ken Yu} and Huang, {Po Chao} and Chen, {Wei Jao}",
year = "1997",
month = "1",
doi = "10.1016/S0899-9007(97)90876-5",
language = "English",
volume = "13",
pages = "32--36",
journal = "Nutrition",
issn = "0899-9007",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition

AU - Yeh, Sung Ling

AU - Chang, Ken Yu

AU - Huang, Po Chao

AU - Chen, Wei Jao

PY - 1997/1

Y1 - 1997/1

N2 - The effect of total parenteral nutrition (TPN) enriched with n-3 or n-6 fatty acids on the concentration of plasma eicosanoids was evaluated in rats. Rats were divided into three groups: the control group (n = 6) was fed a chow diet and infused with saline only. Two experimental groups (n = 11, 13) received TPN solutions at an energy level of 30 kcal/100 g body weight with 40% energy provided as fat. The experimental groups were maintained on TPN for a period of 7 d. The basal TPN solutions were isonitrogenous and identical in nutrient composition except for differences in lipid source. One experimental group received a safflower oil emulsion, whereas the other group received a fish oil emulsion. At the end of the experimental period, plasma 6-keto prostaglandin F(1α), thromboxane B2, bleeding time, lipid peroxidation products, and antioxidant enzymes of liver were analyzed. The results demonstrated that the fish oil group had lower 6-keto prostaglandin F(1α) concentration than the safflower oil group. Also, plasma thromboxane B2 was the lowest in the fish oil group among the three groups. There was no difference in bleeding time among the groups. With regard to liver lipid peroxidation products, malondialdehyde concentration was not higher in the fish oil group, whereas superoxide dismutase and glutathione peroxidase activities were lower in the fish oil group compared with the control and safflower oil groups. The results suggest that TPN prepared with fish oil fat emulsion causes less accumulation of lipid peroxidation products in the liver of rats, and may be beneficial in preventing platelet aggregation.

AB - The effect of total parenteral nutrition (TPN) enriched with n-3 or n-6 fatty acids on the concentration of plasma eicosanoids was evaluated in rats. Rats were divided into three groups: the control group (n = 6) was fed a chow diet and infused with saline only. Two experimental groups (n = 11, 13) received TPN solutions at an energy level of 30 kcal/100 g body weight with 40% energy provided as fat. The experimental groups were maintained on TPN for a period of 7 d. The basal TPN solutions were isonitrogenous and identical in nutrient composition except for differences in lipid source. One experimental group received a safflower oil emulsion, whereas the other group received a fish oil emulsion. At the end of the experimental period, plasma 6-keto prostaglandin F(1α), thromboxane B2, bleeding time, lipid peroxidation products, and antioxidant enzymes of liver were analyzed. The results demonstrated that the fish oil group had lower 6-keto prostaglandin F(1α) concentration than the safflower oil group. Also, plasma thromboxane B2 was the lowest in the fish oil group among the three groups. There was no difference in bleeding time among the groups. With regard to liver lipid peroxidation products, malondialdehyde concentration was not higher in the fish oil group, whereas superoxide dismutase and glutathione peroxidase activities were lower in the fish oil group compared with the control and safflower oil groups. The results suggest that TPN prepared with fish oil fat emulsion causes less accumulation of lipid peroxidation products in the liver of rats, and may be beneficial in preventing platelet aggregation.

KW - 6- keto prostaglandin F(1α)

KW - fish oil emulsion

KW - safflower oil emulsion

KW - thromboxane B

KW - total parenteral nutrition

UR - http://www.scopus.com/inward/record.url?scp=0002663644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002663644&partnerID=8YFLogxK

U2 - 10.1016/S0899-9007(97)90876-5

DO - 10.1016/S0899-9007(97)90876-5

M3 - Article

C2 - 9058445

AN - SCOPUS:0002663644

VL - 13

SP - 32

EP - 36

JO - Nutrition

JF - Nutrition

SN - 0899-9007

IS - 1

ER -