Effects of montelukast on human nasal mucosa

Hsing Won Wang, Jih Chin Lee, Pei Chuan Wu, Yueng Hsiang Chu, Yuan Yung Lin, Li Hsiang Cheng

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Objective: Montelukast is a selective and orally active leukotriene D 4 receptor antagonist often used in treating asthma and allergic rhinitis. Montelukast nasal spray was developed to avoid systemic adverse effects of the drug in vitro. However, the effects of montelukast on human nasal mucosa are not yet fully explored and potential nasal vascular side effects of the drug merit further exploration. First, the effects of montelukast on vasocontractile responses generated by smooth muscles in the vascular structures of human nasal mucosa were investigated directly in vitro. Methods: This study examined the effects of montelukast on human nasal mucosa in terms of mucosa resting tension, vasoconstriction caused by 10 − 6 M methoxamine as a sympathetic mimetic, and electrically induced vasoconstrictions. Results: The results indicated that addition of methoxamine to the incubation medium caused the nasal mucosa to vasocontract in a dose-dependent manner. Addition of montelukast at doses of 10 − 5 M or above elicited a significant vasodilation response to 10 − 6 M methoxamine-induced vasoconstriction. Montelukast could not inhibit electrical field stimulation-induced spike vasoconstriction. Moreover, increase in concentration of montelukast had minimal effect on basal tension of nasal mucosa. Conclusions: The study indicated significant vasodilation on human nasal mucosa under high concentrations of montelukast with a probable α-adrenoceptor antagonism. Hence, the nasal activity of α-adrenergic agonist nasal spray for nasal obstruction may be reduced in those using concomitant (oral or local spray) montelukast.

Original languageEnglish
Pages (from-to)761-765
Number of pages5
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume276
Issue number3
DOIs
Publication statusPublished - Mar 14 2019

Keywords

  • Human nasal mucosa
  • Montelukast
  • Sympathetic function

ASJC Scopus subject areas

  • Otorhinolaryngology

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