Effects of microvascular permeability changes on contrast-enhanced t1 and pharmacokinetic mr imagings after ischemia

Hua Shan Liu, Hsiao Wen Chung, Ming Chung Chou, Michelle Liou, Chao Ying Wang, Hung Wen Kao, Shih Wei Chiang, Chun Jung Juan, Guo Shu Huang, Cheng Yu Chen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - : Brain enhancement on contrast-enhanced T1-weighted imaging (CET1-WI) after ischemic stroke is generally accepted as an indicator of the blood-brain barrier disruption. However, this phenomenon usually starts to become visible at the subacute phase. The purpose of this study was to evaluate the time-course profiles of K, cerebral blood volume (vp), and CET1-WI with early detection of blood-brain barrier changes on K maps and their role for prediction of subsequent hemorrhagic transformation in acute middle cerebral arterial infarct. METHODS - : Twenty-six patients with acute middle cerebral arterial stroke and early spontaneous reperfusion, whose MR images were obtained at predetermined stroke stages, were included. T2*-based MR perfusion-weighted images were acquired using the first-pass pharmacokinetic model to derive K and vp. Parenchymal enhancement observed on maps of K, vp, and CET1-WI at each stage was compared. Association among these measurements and hemorrhagic transformation was analyzed. RESULTS - : K map showed significantly higher parenchymal enhancement in ischemic parenchyma as compared with that of vp map and CET1-WI at early stroke stages (P

Original languageEnglish
Pages (from-to)1872-1877
Number of pages6
JournalStroke
Volume44
Issue number7
DOIs
Publication statusPublished - Jul 2013

Keywords

  • bloodbrain barrier
  • K
  • parenchymal enhancement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

Fingerprint Dive into the research topics of 'Effects of microvascular permeability changes on contrast-enhanced t1 and pharmacokinetic mr imagings after ischemia'. Together they form a unique fingerprint.

  • Cite this

    Liu, H. S., Chung, H. W., Chou, M. C., Liou, M., Wang, C. Y., Kao, H. W., Chiang, S. W., Juan, C. J., Huang, G. S., & Chen, C. Y. (2013). Effects of microvascular permeability changes on contrast-enhanced t1 and pharmacokinetic mr imagings after ischemia. Stroke, 44(7), 1872-1877. https://doi.org/10.1161/STROKEAHA.113.001558