Effects of medium-chain triglyceride in parenteral nutrition on rats undergoing gastrectomy

M. T. Lin, S. L. Yeh, M. L. Kuo, K. Y. Liaw, P. H. Lee, K. J. Chang, W. J. Chen

Research output: Contribution to journalArticle

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Abstract

This study was designed to investigate the effects of pre-infusion with total parenteral nutrition (TPN) using medium-chain triglyceride (MCT) versus long-chain triglyceride (LCT) emulsion as fat sources on hepatic lipids, inflammatory mediators and antioxidant capacity in rats undergoing gastrectomy. Rats with internal jugular catheter, were divided into two groups and received TPN. TPN supplied 300 kcal/kg/d with 39% of the energy provided as fat. All TPN solutions were isonitrogenous and identical in nutrient composition except for the fat emulsion, which was composed of MCT/LCT (1:1) or LCT. After receiving TPN for 5 days the rats underwent partial gastrectomy and were sacrificed 24 h after surgery. The results of the study demonstrated that the MCL/LCT group had lower hepatic lipids than did the LCT group. No differences in interleukin-1β interleukin-6 and tumor necrosis factor-α in peritoneal lavage fluid were observed between the two groups. Erythrocyte glutathione peroxidase activity was significantly higher in the LCT group than the MCT/LCT group, although erythrocyte superoxide dismutase activity did not differ significantly between the two groups. These results suggest that infusion with MCT/LCT before an abdominal operation did not have an effect on modulating the production of inflammatory mediators in the location of the injurious stimulus. However, pre-infusion with MCT/LCT have beneficial effect in improving liver lipid metabolism and reducing oxidative stress in rats with gastrectomy.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalClinical Nutrition
Volume21
Issue number1
DOIs
Publication statusPublished - 2002

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Parenteral Nutrition
Gastrectomy
Triglycerides
Total Parenteral Nutrition
Fats
Emulsions
Liver
Erythrocytes
Parenteral Nutrition Solutions
Peritoneal Lavage
Lipids
Ascitic Fluid
Glutathione Peroxidase
Interleukin-1
Lipid Metabolism
Superoxide Dismutase
Interleukin-6
Oxidative Stress
Neck
Catheters

Keywords

  • Cytokines
  • Gastrectomy
  • Glutathione peroxidase (GSHPx)
  • LCT
  • MCT/LCT
  • Superoxide dismutase (SOD)
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)
  • Medicine (miscellaneous)

Cite this

Lin, M. T., Yeh, S. L., Kuo, M. L., Liaw, K. Y., Lee, P. H., Chang, K. J., & Chen, W. J. (2002). Effects of medium-chain triglyceride in parenteral nutrition on rats undergoing gastrectomy. Clinical Nutrition, 21(1), 39-43. https://doi.org/10.1054/clnu.2001.0501

Effects of medium-chain triglyceride in parenteral nutrition on rats undergoing gastrectomy. / Lin, M. T.; Yeh, S. L.; Kuo, M. L.; Liaw, K. Y.; Lee, P. H.; Chang, K. J.; Chen, W. J.

In: Clinical Nutrition, Vol. 21, No. 1, 2002, p. 39-43.

Research output: Contribution to journalArticle

Lin, MT, Yeh, SL, Kuo, ML, Liaw, KY, Lee, PH, Chang, KJ & Chen, WJ 2002, 'Effects of medium-chain triglyceride in parenteral nutrition on rats undergoing gastrectomy', Clinical Nutrition, vol. 21, no. 1, pp. 39-43. https://doi.org/10.1054/clnu.2001.0501
Lin, M. T. ; Yeh, S. L. ; Kuo, M. L. ; Liaw, K. Y. ; Lee, P. H. ; Chang, K. J. ; Chen, W. J. / Effects of medium-chain triglyceride in parenteral nutrition on rats undergoing gastrectomy. In: Clinical Nutrition. 2002 ; Vol. 21, No. 1. pp. 39-43.
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