Effects of MCT/LCT and LCT emulsions on plasma lipids and nitrogen retention in streptozotocin-induced diabetic rats receiving total parenteral nutrition

Wei J. Chen, Sung Ling Yeh, Y. I P Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study was designed to investigate the effects of emulsions containing medium-chain triacylglycerols (MCT) or long-chain triacylglycerols (LCT) on plasma lipids and nitrogen retention in diabetic rats receiving total parenteral nutrition (TPN). Diabetes was induced in rats by streptozotocin (STZ). Control and diabetic rots were divided into two TPN groups. The TPN groups received solutions at an energy level of 30 kcal/100 g body weight with 37.5% of the nonprotein energy provided as fat. All TPN solutions were isonitrogenous and identical in nutrient composition except for the fat emulsion, which was composed of LCT or MCT/LCT (1:1). The results showed that plasma triacylglycerol (TG), nonesterified fatty acids (NEFA), and β-hydroxybutyrate levels were higher in diabetic rats compared with control rats, whereas plasma insulin levels and nitrogen retention were lower. Plasma glucose levels, TG, NEFA, and β-hydroxybutyrate levels were significantly decreased after TPN administration in diabetic groups. Plasma glucose and TG levels, however, remained higher in diabetic groups than in control groups. No differences in the concentrations of plasma TG, cholesterol, NEFA, β-hydroxybutyrate rate or nitrogen retention were observed between the two diabetic groups. These remits suggest that MCT/LCT infusion did not lead to hyperketonemia and hypercholesterolemia as compared with LCT infusion, and had no beneficial effect on nitrogen retention in rots with STZ-induced diabetes under the present experimental conditions.

Original languageEnglish
Pages (from-to)882-886
Number of pages5
JournalNutrition
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 1997

Fingerprint

Total Parenteral Nutrition
Streptozocin
Emulsions
Triglycerides
Nitrogen
Lipids
Hydroxybutyrates
Nonesterified Fatty Acids
Fats
Parenteral Nutrition Solutions
Glucose
Experimental Diabetes Mellitus
Hypercholesterolemia
Cholesterol
Body Weight
Insulin

Keywords

  • Diabetes mellitus
  • Fat emulsion
  • Long-chain triacylglycerols
  • Medium-chain triacylglycerols
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Surgery

Cite this

Effects of MCT/LCT and LCT emulsions on plasma lipids and nitrogen retention in streptozotocin-induced diabetic rats receiving total parenteral nutrition. / Chen, Wei J.; Yeh, Sung Ling; Wu, Y. I P.

In: Nutrition, Vol. 13, No. 10, 10.1997, p. 882-886.

Research output: Contribution to journalArticle

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abstract = "This study was designed to investigate the effects of emulsions containing medium-chain triacylglycerols (MCT) or long-chain triacylglycerols (LCT) on plasma lipids and nitrogen retention in diabetic rats receiving total parenteral nutrition (TPN). Diabetes was induced in rats by streptozotocin (STZ). Control and diabetic rots were divided into two TPN groups. The TPN groups received solutions at an energy level of 30 kcal/100 g body weight with 37.5{\%} of the nonprotein energy provided as fat. All TPN solutions were isonitrogenous and identical in nutrient composition except for the fat emulsion, which was composed of LCT or MCT/LCT (1:1). The results showed that plasma triacylglycerol (TG), nonesterified fatty acids (NEFA), and β-hydroxybutyrate levels were higher in diabetic rats compared with control rats, whereas plasma insulin levels and nitrogen retention were lower. Plasma glucose levels, TG, NEFA, and β-hydroxybutyrate levels were significantly decreased after TPN administration in diabetic groups. Plasma glucose and TG levels, however, remained higher in diabetic groups than in control groups. No differences in the concentrations of plasma TG, cholesterol, NEFA, β-hydroxybutyrate rate or nitrogen retention were observed between the two diabetic groups. These remits suggest that MCT/LCT infusion did not lead to hyperketonemia and hypercholesterolemia as compared with LCT infusion, and had no beneficial effect on nitrogen retention in rots with STZ-induced diabetes under the present experimental conditions.",
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