Effects of maternal nicotine exposure on lung surfactant system in rats

Chung Ming Chen, Leng-Fang Wang, Tsu Fuh Yeh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Maternal smoking during pregnancy may impair pulmonary function in infants and children, but the exact mechanisms underlying these changes remain to be determined. Timed pregnant Sprague-Dawley rats were injected subcutaneously with nicotine at a dose of 2 mg/kg/ day from days 3-21 of gestation. A control group was injected with saline. Nicotine-treated dams had lower body weights than control dams from gestational days 5-21, and the values reached statistical significance on gestational days 17, 20, and 21. Total lung saturated phosphatidylcholine contents tended to be lower in nicotine-exposed rats than in control rats from postnatal day 21, and the values reached statistical significance on postnatal days 35 and 42. Maternal nicotine exposure significantly increased surfactant protein (SP)-A, SP-B, SP-C, and SP-D mRNA expression on postnatal day 7, and decreased SP-A, SP-B, SP-C, and SP-D mRNA expression on postnatal day 14. In conclusion, maternal nicotine exposure during pregnancy reduces lung surfactant lipids and produces variable changes in surfactant protein gene expression during the late postnatal period. As good surface activity of pulmonary surfactant is essential for normal lung function, these results suggest that derangement of the pulmonary surfactant system may be important in the pathogenesis of impaired pulmonary function in children exposed in utero to nicotine.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalPediatric Pulmonology
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Maternal Exposure
Nicotine
Surface-Active Agents
Lung
Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Pulmonary Surfactants
Protein C
Pregnancy
Messenger RNA
Phosphatidylcholines
Sprague Dawley Rats
Smoking
Body Weight
Mothers
Lipids
Gene Expression
Control Groups
Proteins

Keywords

  • Lung
  • Nicotine
  • Saturated phosphatidylcholine
  • Surfactant protein

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Effects of maternal nicotine exposure on lung surfactant system in rats. / Chen, Chung Ming; Wang, Leng-Fang; Yeh, Tsu Fuh.

In: Pediatric Pulmonology, Vol. 39, No. 2, 02.2005, p. 97-102.

Research output: Contribution to journalArticle

Chen, Chung Ming ; Wang, Leng-Fang ; Yeh, Tsu Fuh. / Effects of maternal nicotine exposure on lung surfactant system in rats. In: Pediatric Pulmonology. 2005 ; Vol. 39, No. 2. pp. 97-102.
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