Effects of magnesium sulfate and lidocaine on cisapride-induced ventricular proarrhythmia in canine heart

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Abstract

Background: Cisapride, a widely used gastrointestinal prokinetic agent, was known to prolong ventricular repolarization and induce torsades de pointes. Magnesium sulfate (MgSO4) or lidocaine was frequently used to treatment torsades de pointes. However, knowledge was limited about the electrophysiological effects of magnesium sulfate or lidocaine on cisapride-induced ventricular arrhythmia. Method: Cisapride (6 mg/kg) was administrated in dogs with complete AV block. The monophasic action potential, QT interval and amplitudes of early afterdepolarization (EAD) were measured before and after MgSO4 (100 mg/kg) or lidocaine (1 mg/kg) administration, respectively. Result: Lidocaine decreased QT interval, biventricular 90% of action potential duration (APD90), amplitudes of EADs, and interventricular difference of APD90. MgSO4 decreased cisapride-induced EADs and interventricular difference of APD90, but did not change QT interval or bilateral ventricular APD90. Moreover, MgSO4 was more effective than lidocaine in suppressing the amplitude of right ventricular EADs (19 ± 11 % versus 8± 4 %, p <0.05) and the amplitude of left ventricular EADs (25± 12 % versus 10± 5 %, p <0.01). Conclusion: Through different electrophysiological mechanisms, MgSO4 and lidocaine were effective drugs in treating cisapride-induced proarrhythmia.

Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalActa Cardiologica Sinica
Volume19
Issue number2
Publication statusPublished - Jun 2003

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Keywords

  • Cisapride
  • Lidocaine
  • Long QT syndrome
  • Magnesium sulfate
  • Torsades de pointes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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