Effects of L-glutamic acid on acid secretion and mucosal blood flow in the rat stomach

Li Hsueh Tsai, Lib Ron Huang, Sheng Hhsuan Chen, Hung Jung Li, Liang Shung Chou

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Abstract

The effect of intravenous administration of L-glutamic acid (L-Glu) on gastric acid secretion and gastric mucosal blood flow (GMBF) in anesthetized rats were investigated. Infusion with synthetic L-Glu alone had no effect on spontaneous acid secretion. However, L-Glu reduced histamine- (2 mg/kg/hr) or oxotremorine- (1 μg/kg/hr) stimulated acid secretion, whereas L-Glu had no effect on acid secretion induced by pentagastrin (8 μg/kg/hr). Furthermore, this inhibitory effect of L-Glu on histamine- or oxotremorine- stimulated acid secretion was blocked by 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non- NMDA receptor antagonist. The effect of L-Glu on gastric mucosal microcirculation in the anesthetized rats was evaluated by using Laser Doppler Flowmetry (LDF). The results showed that L-Glu did not significantly reduce both mucosal and serosal blood flow in stomach. No significant modulatory effect on histamine- or oxotremorine-stimulated increase in GMBF was noted after infusion with L-Glu. It is concluded that L-glutamic acid is capable of the modulating of gastric acid secretion via ionotropic non-NMDA receptors, but do not affect on GMBF. However, L-glutamic acid showed no effect on acid secretion by itself.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalChinese Journal of Physiology
Volume42
Issue number3
Publication statusPublished - Sep 30 1999

Keywords

  • Gastric acid secretion
  • Gastric mucosal blood flow
  • Histamine
  • L-glutamic acid
  • Non-NMDA Receptor
  • Oxotremorine

ASJC Scopus subject areas

  • Physiology

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  • Cite this

    Tsai, L. H., Huang, L. R., Chen, S. H., Li, H. J., & Chou, L. S. (1999). Effects of L-glutamic acid on acid secretion and mucosal blood flow in the rat stomach. Chinese Journal of Physiology, 42(3), 181-187.