Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice

Yunru Liu, Qiongjun Xu, Yaping Ma

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.

METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.

RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).

CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.

Original languageEnglish
Pages (from-to)376-377
Number of pages2
JournalZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Volume32
Issue number5
Publication statusPublished - May 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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