Abstract
OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.
METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.
RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).
CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.
| Original language | English |
|---|---|
| Pages (from-to) | 376-377 |
| Number of pages | 2 |
| Journal | Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases |
| Volume | 32 |
| Issue number | 5 |
| Publication status | Published - May 1 2014 |
| Externally published | Yes |
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- Medicine(all)
Cite this
Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice. / Liu, Yunru; Xu, Qiongjun; Ma, Yaping.
In: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, Vol. 32, No. 5, 01.05.2014, p. 376-377.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice
AU - Liu, Yunru
AU - Xu, Qiongjun
AU - Ma, Yaping
PY - 2014/5/1
Y1 - 2014/5/1
N2 - OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.
AB - OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.
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M3 - Article
VL - 32
SP - 376
EP - 377
JO - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
JF - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
SN - 1001-9391
IS - 5
ER -