Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice

Yunru Liu, Qiongjun Xu, Yaping Ma

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.

METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.

RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).

CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.

Original languageEnglish
Pages (from-to)376-377
Number of pages2
JournalZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases
Volume32
Issue number5
Publication statusPublished - May 1 2014
Externally publishedYes

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Gastric Lavage
Inbred ICR Mouse
Malondialdehyde
Formaldehyde
Lipid Peroxidation
Superoxide Dismutase
Body Weight
Control Groups
Liver
Hypertrophy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{aa95452a830546a0979d921f8e321033,
title = "Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice",
abstract = "OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.",
author = "Yunru Liu and Qiongjun Xu and Yaping Ma",
year = "2014",
month = "5",
day = "1",
language = "English",
volume = "32",
pages = "376--377",
journal = "Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases",
issn = "1001-9391",
publisher = "Tianjin shi lao dong wei sheng yan jiu suo; Tianjin shi lao dong wei sheng huan jing yi xue hui",
number = "5",

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TY - JOUR

T1 - Effects of intragastric administration of formaldehyde on superoxide dismutase activities and malondialdehyde contents in liver of mice

AU - Liu, Yunru

AU - Xu, Qiongjun

AU - Ma, Yaping

PY - 2014/5/1

Y1 - 2014/5/1

N2 - OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.

AB - OBJECTIVE: To study the effects of intragastric administration of formaldehyde on lipid peroxidation in mice.METHODS: Thirty ICR mice were randomly divided into 3 groups: one control group and two experimental groups. The mice were given formaldehyde (the dose is 0, 5 and 20 mg/kg body weight respectively) through intragastric administration once a day for 5 days , and then they were killed. The activities of SOD and the contents of MDA in liver were measured.RESULTS: The activities of SOD in the 20 mg/kg body weight group were significantly lower than the control group (P < 0.05), and the contents of MDA in the 20 mg/kg body weight group were significantly higher than the control group (P < 0.05), and the liver organ coefficient in the 20 mg/kg body weight group is higher than the control group (P < 0.05).CONCLUSION: A certain dose of formaldehyde can destroy the balance of lipid peroxidation in mice, the ability of antioxidation is reduced obviously, and the liver become compensatory hypertrophy.

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JO - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

JF - Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

SN - 1001-9391

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