Effects of influenza vaccine and sun exposure time against laboratory-confirmed influenza hospitalizations among young children during the 2012–13 to 2015–16 influenza seasons

Ching Yun Wang, Yi Hsuan Chang, Li Min Huang, Hsin Chi, Nan Chang Chiu, Luan Yin Chang, Chun Yi Lu, Yhu Chering Huang, Hsiao Chuan Lin, Jian Te Lee, Ching Chuan Liu, Yi Chuan Huang, Yu Huai Ho, Yi Hsuan Tu, Jin Yuan Wang, Daniel Tsung Ning Huang

Research output: Contribution to journalArticle

Abstract

Background: Influenza is a major cause of acute respiratory infection burden worldwide, leading to many hospitalizations. An annual influenza vaccine is believed to be the best way to prevent influenza-related illnesses. We focused on the efficacies of other possible preventive measures such as increasing sun exposure time and dietary supplements to prevent these illnesses. Methods: We conducted a matched-pair case–control study along with the Taiwan Pediatric Infectious Disease Alliance. We included influenza-related hospitalized patients with age ranging from 6 months to 5 years during the 2012–2013, 2013–2014, 2014–2015, and 2015–2016 influenza seasons. The controls were comparable to cases in age, sex, and residential area and had no influenza-related hospitalization records in the same season. We extracted data from vaccination histories and got the patients’ guardians to complete questionnaires. Data were analyzed using conditional logistic regression. Results: We enrolled 1514 children (421 influenza-infected cases and 1093 controls) in the study. We found seasonal influenza vaccination to be an independent protective factor against hospitalizations owing to influenza [p < 0.01; odds ratio (OR), 0.427; 95% confidence interval (CI), 0.306–0.594]. Children with mean sun exposure time of >7 h/week had a significantly lower risk of influenza-related hospitalizations than those with the mean sun exposure time of ≤7 h/week (p < 0.05; OR, 0.667; 95% CI, 0.491–0.906). Conclusions: Seasonal influenza vaccination effectively prevents influenza-related hospitalizations in children aged ≤5 years. Besides, >7 h of sun exposure/week may also be associated with lower risk of influenza-related hospitalizations in children.

Original languageEnglish
Pages (from-to)880-887
Number of pages8
JournalJournal of Microbiology, Immunology and Infection
Volume52
Issue number6
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Hospitalization
  • Influenza
  • Sun exposure time
  • Vaccine effectiveness

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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    Wang, C. Y., Chang, Y. H., Huang, L. M., Chi, H., Chiu, N. C., Chang, L. Y., Lu, C. Y., Huang, Y. C., Lin, H. C., Lee, J. T., Liu, C. C., Huang, Y. C., Ho, Y. H., Tu, Y. H., Wang, J. Y., & Huang, D. T. N. (2019). Effects of influenza vaccine and sun exposure time against laboratory-confirmed influenza hospitalizations among young children during the 2012–13 to 2015–16 influenza seasons. Journal of Microbiology, Immunology and Infection, 52(6), 880-887. https://doi.org/10.1016/j.jmii.2019.09.010