Effects of glutamine-containing total parenteral nutrition on phagocytic activity and anabolic hormone response in rats undergoing gastrectomy

Chen Hsien Lee, Wan-Chun Chiu, Soul-Chin Chen, Chih-Hsiung Wu, Sung-Ling Yeh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: To investigate the effect of glutamine (Gln)-containing parenteral nutrition on phagocytic activity and to elucidate the possible roles of Gln in the secretion of anabolic hormones and nitrogen balance in rats undergoing a gastrectomy. Methods: Rats with an internal jugular catheter were divided into 2 experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN (control), and in the other group, 25% of the total amino acid nitrogen was replaced with Gln. After receiving TPN for 3 d, one-third of the rats in each experimental group were sacrificed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 and 3 d, respectively, after surgery. Plasma, peritoneal lavage fluid (PLF), and urine samples were collected for further analysis. Results: The Gln group had fewer nitrogen losses 1 and 2 d after surgery (d1, 16.6±242.5 vs -233.4±205.9 mg/d, d2, 31.8±238.8 vs -253.4±184.6 mg/d, P

Original languageEnglish
Pages (from-to)817-822
Number of pages6
JournalWorld Journal of Gastroenterology
Volume11
Issue number6
Publication statusPublished - Feb 14 2005

Fingerprint

Total Parenteral Nutrition
Gastrectomy
Glutamine
Hormones
Nitrogen
Parenteral Nutrition Solutions
Peritoneal Lavage
Amino Acids
Ascitic Fluid
Parenteral Nutrition
Neck
Catheters
Urine
Food

Keywords

  • Gastrectomy
  • Glutamine
  • Parenteral nutrition
  • Phagocytosis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Effects of glutamine-containing total parenteral nutrition on phagocytic activity and anabolic hormone response in rats undergoing gastrectomy. / Lee, Chen Hsien; Chiu, Wan-Chun; Chen, Soul-Chin; Wu, Chih-Hsiung; Yeh, Sung-Ling.

In: World Journal of Gastroenterology, Vol. 11, No. 6, 14.02.2005, p. 817-822.

Research output: Contribution to journalArticle

@article{ad836885a05947e0bf1ff95988c0e71f,
title = "Effects of glutamine-containing total parenteral nutrition on phagocytic activity and anabolic hormone response in rats undergoing gastrectomy",
abstract = "Aim: To investigate the effect of glutamine (Gln)-containing parenteral nutrition on phagocytic activity and to elucidate the possible roles of Gln in the secretion of anabolic hormones and nitrogen balance in rats undergoing a gastrectomy. Methods: Rats with an internal jugular catheter were divided into 2 experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN (control), and in the other group, 25{\%} of the total amino acid nitrogen was replaced with Gln. After receiving TPN for 3 d, one-third of the rats in each experimental group were sacrificed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 and 3 d, respectively, after surgery. Plasma, peritoneal lavage fluid (PLF), and urine samples were collected for further analysis. Results: The Gln group had fewer nitrogen losses 1 and 2 d after surgery (d1, 16.6±242.5 vs -233.4±205.9 mg/d, d2, 31.8±238.8 vs -253.4±184.6 mg/d, P",
keywords = "Gastrectomy, Glutamine, Parenteral nutrition, Phagocytosis, Gastrectomy, Glutamine, Parenteral nutrition, Phagocytosis",
author = "Lee, {Chen Hsien} and Wan-Chun Chiu and Soul-Chin Chen and Chih-Hsiung Wu and Sung-Ling Yeh",
year = "2005",
month = "2",
day = "14",
language = "English",
volume = "11",
pages = "817--822",
journal = "World Journal of Gastroenterology",
issn = "1007-9327",
publisher = "WJG Press",
number = "6",

}

TY - JOUR

T1 - Effects of glutamine-containing total parenteral nutrition on phagocytic activity and anabolic hormone response in rats undergoing gastrectomy

AU - Lee, Chen Hsien

AU - Chiu, Wan-Chun

AU - Chen, Soul-Chin

AU - Wu, Chih-Hsiung

AU - Yeh, Sung-Ling

PY - 2005/2/14

Y1 - 2005/2/14

N2 - Aim: To investigate the effect of glutamine (Gln)-containing parenteral nutrition on phagocytic activity and to elucidate the possible roles of Gln in the secretion of anabolic hormones and nitrogen balance in rats undergoing a gastrectomy. Methods: Rats with an internal jugular catheter were divided into 2 experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN (control), and in the other group, 25% of the total amino acid nitrogen was replaced with Gln. After receiving TPN for 3 d, one-third of the rats in each experimental group were sacrificed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 and 3 d, respectively, after surgery. Plasma, peritoneal lavage fluid (PLF), and urine samples were collected for further analysis. Results: The Gln group had fewer nitrogen losses 1 and 2 d after surgery (d1, 16.6±242.5 vs -233.4±205.9 mg/d, d2, 31.8±238.8 vs -253.4±184.6 mg/d, P

AB - Aim: To investigate the effect of glutamine (Gln)-containing parenteral nutrition on phagocytic activity and to elucidate the possible roles of Gln in the secretion of anabolic hormones and nitrogen balance in rats undergoing a gastrectomy. Methods: Rats with an internal jugular catheter were divided into 2 experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN (control), and in the other group, 25% of the total amino acid nitrogen was replaced with Gln. After receiving TPN for 3 d, one-third of the rats in each experimental group were sacrificed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 and 3 d, respectively, after surgery. Plasma, peritoneal lavage fluid (PLF), and urine samples were collected for further analysis. Results: The Gln group had fewer nitrogen losses 1 and 2 d after surgery (d1, 16.6±242.5 vs -233.4±205.9 mg/d, d2, 31.8±238.8 vs -253.4±184.6 mg/d, P

KW - Gastrectomy

KW - Glutamine

KW - Parenteral nutrition

KW - Phagocytosis

KW - Gastrectomy

KW - Glutamine

KW - Parenteral nutrition

KW - Phagocytosis

UR - http://www.scopus.com/inward/record.url?scp=14544304548&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14544304548&partnerID=8YFLogxK

M3 - Article

C2 - 15682473

AN - SCOPUS:14544304548

VL - 11

SP - 817

EP - 822

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

SN - 1007-9327

IS - 6

ER -