Effects of glutamine-containing total parenteral nutrition on phagocytic activity and anabolic hormone response in rats undergoing gastrectomy

Chen Hsien Lee, Wan-Chun Chiu, Soul-Chin Chen, Chih-Hsiung Wu, Sung-Ling Yeh

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Aim: To investigate the effect of glutamine (Gln)-containing parenteral nutrition on phagocytic activity and to elucidate the possible roles of Gln in the secretion of anabolic hormones and nitrogen balance in rats undergoing a gastrectomy. Methods: Rats with an internal jugular catheter were divided into 2 experimental groups and received total parenteral nutrition (TPN). The TPN solutions were isonitrogenous and identical in nutrient compositions except for differences in amino acid content. One group received conventional TPN (control), and in the other group, 25% of the total amino acid nitrogen was replaced with Gln. After receiving TPN for 3 d, one-third of the rats in each experimental group were sacrificed as the baseline group. The remaining rats underwent a partial gastrectomy and were killed 1 and 3 d, respectively, after surgery. Plasma, peritoneal lavage fluid (PLF), and urine samples were collected for further analysis. Results: The Gln group had fewer nitrogen losses 1 and 2 d after surgery (d1, 16.6±242.5 vs -233.4±205.9 mg/d, d2, 31.8±238.8 vs -253.4±184.6 mg/d, P

Original languageEnglish
Pages (from-to)817-822
Number of pages6
JournalWorld Journal of Gastroenterology
Issue number6
Publication statusPublished - Feb 14 2005



  • Gastrectomy
  • Glutamine
  • Parenteral nutrition
  • Phagocytosis

ASJC Scopus subject areas

  • Gastroenterology

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