Effects of garlic oil on interleukin-6 mediated cardiac hypertrophy in hypercholesterol-fed hamsters

You Liang Hsieh, Peiying Pai, Tsung Jung Ho, Li Chin Chung, Yi Chang Cheng, Chieh Hsi Wu, Ming Jen Fan, Cecilia Hsuan Day, Chia Yao Shen, Chih Yang Huang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hypercholesterol diets are the major causes of cardiac hypertrophy and various cardiac disorders. The purpose of this study is to evaluate the effects of garlic oil on cardiac hypertrophy induced by hypercholesterol diets. Golden Syrian hamsters were fed with 2% cholesterol or 2% cholesterol plus 1% garlic oil for 2 months. Heart architecture changes were measured by hematoxylin-eosin staining and the molecular mechanism was determined by western blotting. Garlic oil reduced whole-heart weight to bone weight ratio, and left ventricle weight to bone weight ratio in the cholesterol-fed group. Moreover, the garlic oil group showed significantly reduced interleukin-6, phosphorylated (p)-extracellular signal-regulated kinase-5, p-mitogen-activated protein kinase-5, calcineurin, nuclear transcription factor of nuclear factor of activated T-cells-3 and p-GATA binding protein 4 when compared with the cholesterol group. However, no changes were observed in gp-130, signal transducer and activator of transcription-3, p-P38 and p-Jun N-terminal kinases protein levels in all groups. The results show that garlic oil may be useful in the treatment of hypertrophy-associated cardiovascular diseases.

Original languageEnglish
Pages (from-to)320-328
Number of pages9
JournalChinese Journal of Physiology
Volume57
Issue number6
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • Garlic oil
  • Heart
  • Hypercholesterol
  • Hypertrophy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Medicine(all)

Fingerprint Dive into the research topics of 'Effects of garlic oil on interleukin-6 mediated cardiac hypertrophy in hypercholesterol-fed hamsters'. Together they form a unique fingerprint.

  • Cite this

    Hsieh, Y. L., Pai, P., Ho, T. J., Chung, L. C., Cheng, Y. C., Wu, C. H., Fan, M. J., Day, C. H., Shen, C. Y., & Huang, C. Y. (2014). Effects of garlic oil on interleukin-6 mediated cardiac hypertrophy in hypercholesterol-fed hamsters. Chinese Journal of Physiology, 57(6), 320-328. https://doi.org/10.4077/CJP.2014.BAC261