Effects of fungal-derived high molecular weight chitosan on 5-fluorouracil-induced adverse reactions

Yih Huei Uen, Ying Jan Wang, Town Ming Hsu, Mei Huei Chen, Hing Yuen Chan, Yuan Soon Ho, Shyr Yi Lin

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of fungal-derived high molecular weight chitosan (HMWC) on the prevention of 5-fluorouracil (5-FU)-induced side-effects were studied in a sarcoma-bearing mice model. 5-FU (12.5mg/kg) was gargled into the mice with or without HMWC (25, 75, and 150mg/kg) every 12 h for consecutive 8 or 16 days in different experiments. The HMWC (25-150 mg/kg) exerted no toxicity and did not interfere with the anti-tumor activity of 5-FU on sarcoma-bearing mice. HMWC in a higher dose (150 mg/kg) partially protected 5-FU-induced cytotoxicity on peripheral leukocytes, lymphocytes, and bone marrow CD-19 positive cells. HMWC reversed the 5-FU suppression of intestine sucrase activity and attenuated the 5-FU-induced diarrhea. Bone marrow cells micronucleus and DNA comet assays demonstrated that HMWC significantly reversed 5-FU-induced genome toxicity to marrow cells. These results suggested that fungal-derived HMWC attenuated the 5-FU-induced bone marrow and gastrointestinal toxicity, and has the potential for clinical applications in the future.

Original languageEnglish
Pages (from-to)458-472
Number of pages15
JournalJournal of Bioactive and Compatible Polymers
Volume23
Issue number5
DOIs
Publication statusPublished - Sep 2008

Keywords

  • 5-fluorouracil
  • Cancer chemotherapy
  • Chitosan
  • Comet assay
  • Cytotoxicity

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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