Effects of frying oil and Houttuynia cordata thunb on xenobiotic-metabolizing enzyme system of rodents

Ya Yen Chen, Chiao Ming Chen, Pi Yu Chao, Tsan J. Chang, Jen Fang Liu

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6 Citations (Scopus)

Abstract

Aim: To evaluate the effects of frying oil and Houttuynia cordata Thunb (H. cordata), a vegetable traditionally consumed in Taiwan, on the xenobiotic-metabolizing enzyme system of rodents. Methods: Forty-eight Sprague-Dawley rats were fed with a diet containing 0%, 2% or 5% H. cordata powder and 15% fresh soybean oil or 24-h oxidized frying oil (OFO) for 28 d respectively. The level of microsomal protein, total cytochrome 450 content (CYP450) and enzyme activities including NADPH reductase, ethoxyresorufin O-deethylase (EROD), pentoxyresorufin O-dealkylase (PROD), aniline hydroxylase (ANH), aminopyrine demethylase (AMD), and quinone reductase (QR) were determined. QR represented phase II enzymes, the rest of the enzymes tested represented phase I enzymes. Results: The oxidized frying oil feeding produced a significant increase in phase I and II enzyme systems, including the content of CYP450 and microsomal protein, and the activities of NADPH reductase, EROD, PROD, ANH, AMD and QR in rats (P

Original languageEnglish
Pages (from-to)389-392
Number of pages4
JournalWorld Journal of Gastroenterology
Volume11
Issue number3
Publication statusPublished - Jan 21 2005

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Keywords

  • Frying oil
  • Houttuynia cordata thunb
  • Xenobiotic-metabolizing enzyme system

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Chen, Y. Y., Chen, C. M., Chao, P. Y., Chang, T. J., & Liu, J. F. (2005). Effects of frying oil and Houttuynia cordata thunb on xenobiotic-metabolizing enzyme system of rodents. World Journal of Gastroenterology, 11(3), 389-392.