Effects of fish oil in parenteral nutrition

Wei J. Chen, Sung Ling Yeh

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

OBJECTIVE: Fish oil is a rich source of ω-3 fatty acids (FAs), especially eicosapentaenoic acid and docosahexaenoic acid. The existing data suggest that eicosapentaenoic acid and docosahexaenoic acid are the active agents in fish oil. A number of clinical trials have shown that dietary fish oil supplementation has antiatherogenic properties and immunomodulation effects. Fish oils are not used widely in parenteral nutrition because fish oil emulsions have not been commercially available until very recently. Studies concerning the use of fish oil in parenteral route are rare. METHODS: We reviewed the effect of parenteral fish oil infusion on lipid metabolism and immune response in normal and disease conditions. RESULTS: Studies showed that the main effects of parenteral infusion of fish oil are: 1) incorporation of ω-3 FAs into cellular membranes of many cell populations that consequently influence the disease process of some disease conditions, 2) an effect on eicosanoid metabolism leading to a decrease in platelet aggregation and thrombosis, 3) amelioration of the severity of diet-induced hepatic steatosis, 4) less accumulation of lipid peroxidation products in liver tissue, and 5) immunomodulation effects and therapeutic benefits in animal disease models or various disease conditions of humans. Most of these studies suggested that parenteral infusion of ω-3 FAs have clinical beneficial effects comparable to those of dietary administration. However, different effects of ω-3 and ω-6 FAs in some situations has been reported. For example, plasma triacylglycerol levels were not lowered after fish oil infusion in normal or diabetic rats when compared with those of safflower oil or soybean oil infusion. The reason for the difference remain unclear. CONCLUSION: The metabolic and immunologic effects of parenteral use of ω-3 FAs requires further evaluation, especially in some disease conditions.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalNutrition
Volume19
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

Fingerprint

Fish Oils
Parenteral Nutrition
Fatty Acids
Parenteral Infusions
Eicosapentaenoic Acid
Immunomodulation
Docosahexaenoic Acids
Safflower Oil
Unsaturated Dietary Fats
Animal Disease Models
Soybean Oil
Eicosanoids
Liver
Therapeutic Uses
Emulsions
Platelet Aggregation
Lipid Metabolism
Lipid Peroxidation
Triglycerides
Thrombosis

Keywords

  • ω-3 fatty acids
  • Eicosanoids
  • Fish oil
  • Immunomodulation
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Surgery

Cite this

Effects of fish oil in parenteral nutrition. / Chen, Wei J.; Yeh, Sung Ling.

In: Nutrition, Vol. 19, No. 3, 01.03.2003, p. 275-279.

Research output: Contribution to journalArticle

Chen, Wei J. ; Yeh, Sung Ling. / Effects of fish oil in parenteral nutrition. In: Nutrition. 2003 ; Vol. 19, No. 3. pp. 275-279.
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