Effects of fish oil and spirulina on oxidative stress and inflammation in hypercholesterolemic hamsters

Miriam Adoyo Muga, Jane C J Chao

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Altered plasma lipids, oxidative stress, and inflammation have been involved in the pathogenesis of cardiovascular disease. Fish oil has shown inconclusive effects on plasma lipids and oxidative stress. Spirulina has both cholesterol lowering and antioxidant properties. However, the effect of fish oil and spirulina on hypercholesterolemia has not been studied. We investigated the effects of fish oil, spirulina, and their combination on hypercholesterolemia. Methods: The hamsters were divided into 7 groups: control, high cholesterol (HF), fish oil (post FO), spirulina (post SP), and a combination of fish oil and spirulina (post SF, pre-SF, and HF + SF) groups. The HF and HF + SF groups were given a high cholesterol diet for 8 weeks. The post FO, post SP, and post SF groups were given a high cholesterol diet for 4 weeks and then the treatment for 4 weeks. The pre-SF group was given the combined treatment for 4 weeks and then a high cholesterol diet for 4 weeks. Results: The HF and HF + SF groups altered plasma lipids, increased oxidative stress, inhibited antioxidants, and increased inflammation. While the post FO group increased plasma lipids and was more atherogenic. The vice versa was observed in spirulina-treated group. Both the post SP and post SF groups inhibited oxidative stress and increased antioxidant status, and post FO and post SP diets regulated pro-inflammatory cytokines to near the control levels. Conclusions: Both single treatment of fish oil or spirulina inhibit oxidative stress and inflammation. Treatment with a combination of fish oil and spirulina (post SF) may be beneficial for diet-induced hypercholesterolemic hamsters.

Original languageEnglish
Article number470
JournalBMC Complementary and Alternative Medicine
Volume14
Issue number1
DOIs
Publication statusPublished - Dec 6 2014

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Spirulina
Fish Oils
Cricetinae
Oxidative Stress
Inflammation
Cholesterol
Diet
Lipids
Antioxidants
Hypercholesterolemia
Cardiovascular Diseases

Keywords

  • Fish oil
  • Hypercholesterolemia
  • Inflammation
  • Oxidative stress
  • Spirulina

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Effects of fish oil and spirulina on oxidative stress and inflammation in hypercholesterolemic hamsters. / Muga, Miriam Adoyo; Chao, Jane C J.

In: BMC Complementary and Alternative Medicine, Vol. 14, No. 1, 470, 06.12.2014.

Research output: Contribution to journalArticle

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