Effects of febuxostat on renal function in patients with chronic kidney disease: A systematic review and meta-analysis

Tsu Chen Lin, Lie Yee Hung, Ying Chun Chen, Wei Cheng Lo, Chun Hung Lin, Ka Wai Tam, Mei Yi Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND/OBJECTIVE: Hyperuricemia has been proven to be an independent risk factor for chronic kidney disease (CKD). However, the role of hyperuricemia in the progression of CKD remains unclear. Thus, we performed a systematic review and meta-analysis to evaluate the efficacy and safety of febuxostat, a first line urate-lowering agent, in CKD patients with hyperuricemia. METHODS: We have systematically searched for randomized controlled trials assessing the efficacy and safety of febuxostat versus control in CKD patients with hyperuricemia through MEDLINE, PubMed, EMBASE, and Cochrane databases. All statistical analyses were conducted by using the statistical package Review Manager, version 5.3.5. Heterogeneity was assessed using the Cochrane Q and I tests and summary statistics were reported with 95% confidence interval. Two-tailed test was used for analysis and a P value of <.05 is considered statistically significant. RESULTS: Eleven eligible trials with 1317 participants were included in the meta-analysis. A significant reduction in serum uric acid was found in the febuxostat treated group. Also, a significant higher eGFR was found in the febuxostat treated group among CKD stage 3 and 4 patients. No significant difference of major complication or death was identified between treatment and control groups. CONCLUSIONS: The meta-analysis showed that other than its urate-lowering effect, febuxostat presented a reno-protective effect in CKD patients. More studies with larger sample sizes and higher quality are required to clarify the role of febuxostat use in the progression of CKD.

Original languageEnglish
Pages (from-to)e16311
JournalMedicine
Volume98
Issue number29
DOIs
Publication statusPublished - Jul 1 2019

Keywords

  • Disease Progression
  • Febuxostat/pharmacology
  • Glomerular Filtration Rate/drug effects
  • Gout Suppressants/pharmacology
  • Humans
  • Renal Insufficiency, Chronic/blood
  • Uric Acid/blood

ASJC Scopus subject areas

  • Medicine(all)

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