Abstract
We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.
| Original language | English |
|---|---|
| Pages (from-to) | 291-297 |
| Number of pages | 7 |
| Journal | Biochimica et Biophysica Acta - Lipids and Lipid Metabolism |
| Volume | 664 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - May 22 1981 |
| Externally published | Yes |
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Keywords
- (Rat aorta, Platelet)
- Arachidonate metabolism
- Atherosclerosis
- Estradiol
- Prostacyclin production
- Thromboxane synthesis
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Endocrinology
- Medicine(all)
Cite this
Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats. / Wen-Chang, Chang; Junko, Nakao; Tomohiro, Neichi; Hajime, Orimo; Sei-Itsu, Murota.
In: Biochimica et Biophysica Acta - Lipids and Lipid Metabolism, Vol. 664, No. 2, 22.05.1981, p. 291-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats
AU - Wen-Chang, Chang
AU - Junko, Nakao
AU - Tomohiro, Neichi
AU - Hajime, Orimo
AU - Sei-Itsu, Murota
PY - 1981/5/22
Y1 - 1981/5/22
N2 - We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.
AB - We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.
KW - (Rat aorta, Platelet)
KW - Arachidonate metabolism
KW - Atherosclerosis
KW - Estradiol
KW - Prostacyclin production
KW - Thromboxane synthesis
UR - http://www.scopus.com/inward/record.url?scp=0019863229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019863229&partnerID=8YFLogxK
U2 - 10.1016/0005-2760(81)90052-7
DO - 10.1016/0005-2760(81)90052-7
M3 - Article
C2 - 6788092
AN - SCOPUS:0019863229
VL - 664
SP - 291
EP - 297
JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
SN - 1388-1981
IS - 2
ER -