Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats

Chang Wen-Chang; Nakao Junko; Neichi Tomohiro; Orimo Hajime; Murota Sei-Itsu

doi:10.1016/0005-2760(81)90052-7

Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats

Chang Wen-Chang, Nakao Junko, Neichi Tomohiro, Orimo Hajime, Murota Sei-Itsu

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.

Original language	English
Pages (from-to)	291-297
Number of pages	7
Journal	Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
Volume	664
Issue number	2
DOIs	https://doi.org/10.1016/0005-2760(81)90052-7
Publication status	Published - May 22 1981
Externally published	Yes

Keywords

(Rat aorta, Platelet)
Arachidonate metabolism
Atherosclerosis
Estradiol
Prostacyclin production
Thromboxane synthesis

ASJC Scopus subject areas

Biochemistry
Biophysics
Endocrinology
Medicine(all)

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Cite this

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title = "Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats",

abstract = "We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.",

keywords = "(Rat aorta, Platelet), Arachidonate metabolism, Atherosclerosis, Estradiol, Prostacyclin production, Thromboxane synthesis",

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AU - Wen-Chang, Chang

AU - Junko, Nakao

AU - Tomohiro, Neichi

AU - Hajime, Orimo

AU - Sei-Itsu, Murota

PY - 1981/5/22

Y1 - 1981/5/22

N2 - We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.

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