Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats

Chang Wen-Chang, Nakao Junko, Neichi Tomohiro, Orimo Hajime, Murota Sei-Itsu

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27 Citations (Scopus)

Abstract

We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.

Original languageEnglish
Pages (from-to)291-297
Number of pages7
JournalBiochimica et Biophysica Acta - Lipids and Lipid Metabolism
Volume664
Issue number2
DOIs
Publication statusPublished - May 22 1981
Externally publishedYes

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Keywords

  • (Rat aorta, Platelet)
  • Arachidonate metabolism
  • Atherosclerosis
  • Estradiol
  • Prostacyclin production
  • Thromboxane synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Endocrinology
  • Medicine(all)

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