Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma

START Safety Committee and Investigators, START Investigators

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Study objectives: Asthmatic patients lose lung function faster than normal subjects. The effectiveness of early intervention with inhaled corticosteroids on this decline in lung function is not established in recent-onset disease. Design: The Inhaled Steroid Treatment as Regular Therapy in Early Asthma study was a randomized, double-blind study in 7,165 patients (5 to 66 years old), with persistent asthma for < 2 years to determine whether early intervention with low-dose inhaled budesonide prevents severe asthma-related events and the decline in lung function. Patients received budesonide (200 μg qd for children < 11 years old and 400 μg qd for others) or placebo for 3 years in addition to usual asthma medications. Results: Treatment with budesonide significantly improved prebronchodilator and postbronchodilator FEV1 percentage of predicted and reduced the mean declines from baseline for postbronchodilator FEV1 at 1 year and 3 years: - 0.62% and - 1.79% for budesonide and - 2.11% and - 2.68% for placebo, respectively (p < 0.001). The decline was more marked for male patients, active smokers, and patients > 18 years old, and the smallest treatment effects were in adolescents. Conclusions: Long-term, once-daily treatment with low-dose budesonide improved both prebronchodilator and postbronchodilator FEV1 in patients with recent-onset, persistent asthma, and reduced the loss of lung function over time.

Original languageEnglish
Pages (from-to)1478-1485
Number of pages8
JournalChest
Volume129
Issue number6
DOIs
Publication statusPublished - Jan 1 2006

Fingerprint

Budesonide
Asthma
Lung
Therapeutics
Double-Blind Method
Adrenal Cortex Hormones
Steroids

Keywords

  • Asthma
  • Early intervention
  • Inhaled corticosteroids
  • Lung function

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

START Safety Committee and Investigators, & START Investigators (2006). Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. Chest, 129(6), 1478-1485. https://doi.org/10.1378/chest.129.6.1478

Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. / START Safety Committee and Investigators; START Investigators.

In: Chest, Vol. 129, No. 6, 01.01.2006, p. 1478-1485.

Research output: Contribution to journalArticle

START Safety Committee and Investigators & START Investigators 2006, 'Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma', Chest, vol. 129, no. 6, pp. 1478-1485. https://doi.org/10.1378/chest.129.6.1478
START Safety Committee and Investigators, START Investigators. Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. Chest. 2006 Jan 1;129(6):1478-1485. https://doi.org/10.1378/chest.129.6.1478
START Safety Committee and Investigators ; START Investigators. / Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthma. In: Chest. 2006 ; Vol. 129, No. 6. pp. 1478-1485.
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AU - Ott, Günter

AU - Zarkovic, Jasminka

AU - Schulheim, Andrea

AU - Götz, Manfred

AU - Schinko, Herwig

AU - Thomüller, Ingrid

AU - De Backer, Wilfried

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AU - Verleden, Geert

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AU - Pavelková, Ludmila

AU - Broź, Pavel

AU - Ohnutková, Eva

AU - Novotná, Bronislava

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AU - Krćmová, Irena

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AB - Study objectives: Asthmatic patients lose lung function faster than normal subjects. The effectiveness of early intervention with inhaled corticosteroids on this decline in lung function is not established in recent-onset disease. Design: The Inhaled Steroid Treatment as Regular Therapy in Early Asthma study was a randomized, double-blind study in 7,165 patients (5 to 66 years old), with persistent asthma for < 2 years to determine whether early intervention with low-dose inhaled budesonide prevents severe asthma-related events and the decline in lung function. Patients received budesonide (200 μg qd for children < 11 years old and 400 μg qd for others) or placebo for 3 years in addition to usual asthma medications. Results: Treatment with budesonide significantly improved prebronchodilator and postbronchodilator FEV1 percentage of predicted and reduced the mean declines from baseline for postbronchodilator FEV1 at 1 year and 3 years: - 0.62% and - 1.79% for budesonide and - 2.11% and - 2.68% for placebo, respectively (p < 0.001). The decline was more marked for male patients, active smokers, and patients > 18 years old, and the smallest treatment effects were in adolescents. Conclusions: Long-term, once-daily treatment with low-dose budesonide improved both prebronchodilator and postbronchodilator FEV1 in patients with recent-onset, persistent asthma, and reduced the loss of lung function over time.

KW - Asthma

KW - Early intervention

KW - Inhaled corticosteroids

KW - Lung function

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