Abstract
Background and Objectives Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide, and is the second leading cause of cancer death in Taiwan. E-cadherin is an epithelial cell adhesion molecule, and decreased E-cadherin expression in HCC is associated with a poor prognosis. This study investigates the effects of single nucleotide polymorphisms (SNPs) in the E-cadherin/CDH1 gene promoter on the risk and clinicopathological characteristics of HCC Methods 131 HCC patients and 347 controls were recruited for this study. Genetic polymorphisms of CDH1-160 and-347 were analyzed by PCR-RFLP genotyping analysis. Results After adjusting for other confounders, results show that individuals with the CDH1-347G/GA or GA/GA polymorphic genotypes had a significantly higher risk of developing HCC than those with the wild-type (G/G) genotype (adjusted odds ratio=2.477; 95%CI: 1.421-4.319). Furthermore, patients with HCC with at least one mutant A allele of CDH1-160 had a 4.031-fold risk of progressing to stage III or IV. Conclusions This study shows that SNPs in CDH1-347 gene are associated with an increased risk of HCC, and at least one mutant A allele of CDH1-160 gene is associated with the development of stage III or IV of HCC in Taiwanese.
| Original language | English |
|---|---|
| Pages (from-to) | 299-304 |
| Number of pages | 6 |
| Journal | Journal of Surgical Oncology |
| Volume | 104 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Sep 1 2011 |
Fingerprint
Keywords
- E-cadherin
- genetic polymorphism
- hepatocellular carcinoma
ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular carcinoma. / Chien, Ming Hsien; Yeh, Kun Tu; Li, Yi Ching; Hsieh, Yi Hsien; Lin, Chien-Huang; Weng, Meng Shih; Kuo, Wu Hsien; Yang, Shun Fa.
In: Journal of Surgical Oncology, Vol. 104, No. 3, 01.09.2011, p. 299-304.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathological development of hepatocellular carcinoma
AU - Chien, Ming Hsien
AU - Yeh, Kun Tu
AU - Li, Yi Ching
AU - Hsieh, Yi Hsien
AU - Lin, Chien-Huang
AU - Weng, Meng Shih
AU - Kuo, Wu Hsien
AU - Yang, Shun Fa
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Background and Objectives Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide, and is the second leading cause of cancer death in Taiwan. E-cadherin is an epithelial cell adhesion molecule, and decreased E-cadherin expression in HCC is associated with a poor prognosis. This study investigates the effects of single nucleotide polymorphisms (SNPs) in the E-cadherin/CDH1 gene promoter on the risk and clinicopathological characteristics of HCC Methods 131 HCC patients and 347 controls were recruited for this study. Genetic polymorphisms of CDH1-160 and-347 were analyzed by PCR-RFLP genotyping analysis. Results After adjusting for other confounders, results show that individuals with the CDH1-347G/GA or GA/GA polymorphic genotypes had a significantly higher risk of developing HCC than those with the wild-type (G/G) genotype (adjusted odds ratio=2.477; 95%CI: 1.421-4.319). Furthermore, patients with HCC with at least one mutant A allele of CDH1-160 had a 4.031-fold risk of progressing to stage III or IV. Conclusions This study shows that SNPs in CDH1-347 gene are associated with an increased risk of HCC, and at least one mutant A allele of CDH1-160 gene is associated with the development of stage III or IV of HCC in Taiwanese.
AB - Background and Objectives Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide, and is the second leading cause of cancer death in Taiwan. E-cadherin is an epithelial cell adhesion molecule, and decreased E-cadherin expression in HCC is associated with a poor prognosis. This study investigates the effects of single nucleotide polymorphisms (SNPs) in the E-cadherin/CDH1 gene promoter on the risk and clinicopathological characteristics of HCC Methods 131 HCC patients and 347 controls were recruited for this study. Genetic polymorphisms of CDH1-160 and-347 were analyzed by PCR-RFLP genotyping analysis. Results After adjusting for other confounders, results show that individuals with the CDH1-347G/GA or GA/GA polymorphic genotypes had a significantly higher risk of developing HCC than those with the wild-type (G/G) genotype (adjusted odds ratio=2.477; 95%CI: 1.421-4.319). Furthermore, patients with HCC with at least one mutant A allele of CDH1-160 had a 4.031-fold risk of progressing to stage III or IV. Conclusions This study shows that SNPs in CDH1-347 gene are associated with an increased risk of HCC, and at least one mutant A allele of CDH1-160 gene is associated with the development of stage III or IV of HCC in Taiwanese.
KW - E-cadherin
KW - genetic polymorphism
KW - hepatocellular carcinoma
UR - http://www.scopus.com/inward/record.url?scp=80051503331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80051503331&partnerID=8YFLogxK
U2 - 10.1002/jso.21929
DO - 10.1002/jso.21929
M3 - Article
C2 - 21462191
AN - SCOPUS:80051503331
VL - 104
SP - 299
EP - 304
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
SN - 0022-4790
IS - 3
ER -