Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer

Ming Hsien Chien, Lin Shih Shen Chou, Tsung Te Chung, Chien Huang Lin, Ming Yung Chou, Meng Shih Weng, Shun Fa Yang, Mu Kuan Chen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background This study investigates the association between polymorphism in the E-cadherin/CDH1 promoter region and the risk and progression of oral cancer. Methods Genetic polymorphisms of CDH1-160 and -347 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 347 noncancer controls and in 251 patients with oral cancer. Results The statistical analysis showed that subjects with at least 1 varied GA allele of CDH1-347 polymorphic genotypes or combinations of the CDH1-160 CA/-347 GGA, CDH1-160 CC/-347 GGA, or CDH1-160 CC/-347 GAGA genotypes had a significantly higher risk, whereas subjects with CDH1-160 C/A or A/A had a significantly lower risk of developing oral cancer than those with wild-type genotypes. Furthermore, elderly patients with the CDH1-347 G/GA or GA/GA genotype were associated with a higher incidence in lymph node metastasis than were those with the G/G genotype. Conclusions These results suggest that CDH1-347 polymorphisms are associated with increased risks of oral cancer, and may be a predictive factor for tumor lymph node metastasis.

Original languageEnglish
Pages (from-to)405-411
Number of pages7
JournalHead and Neck
Volume34
Issue number3
DOIs
Publication statusPublished - Mar 2012

Keywords

  • betel nut chewing
  • E-cadherin
  • genetic polymorphism
  • oral cancer
  • tobacco consumption

ASJC Scopus subject areas

  • Otorhinolaryngology

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