Effects of different extracellular matrices and growth factor immobilization on biodegradability and biocompatibility of macroporous bacterial cellulose

Yung Kai Lin, Ko Hua Chen, Keng Liang Ou, Min Liu

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

To improve the biocompatibility of bacterial cellulose hydrogel (BCHG), different extracellular matrices (ECMs; collagen, elastin, and hyaluronan) and growth factors (B-FGF, H-EGF, and KGF) were immobilized onto macroporous BCHG. The microstructure of BCHG had inter-connective channels that were well-integrated with the alginate gel. The alginate gel formed a semi-penetrate hydrogel that allowed the ECM and growth factor to diffuse under physiological conditions. The H-EGF and collagen-modified BCHG supported the growth of human skin fibroblast. The improved BCHG was biocompatible and exhibited desirable skin substitute characteristics that could be used as a deliver vehicle for therapeutic compounds during wound healing.

Original languageEnglish
Pages (from-to)508-518
Number of pages11
JournalJournal of Bioactive and Compatible Polymers
Volume26
Issue number5
DOIs
Publication statusPublished - Sep 2011

Keywords

  • bacterial cellulose
  • biocompatibility
  • biodegradability
  • extracellular matrix
  • growth factor
  • hydrogel
  • wound healing

ASJC Scopus subject areas

  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry
  • Bioengineering

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