Effects of cocaine on human nasal mucosa

S. H. Wang, H. W. Wang, J. Y. Wang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. Results showed that cocaine antagonized methoxamine and inhibited field stimulation. The drug increased resting tension in human nasal mucosa in vitro through direct actions and potentiated mucosal contractions by norepinephrine and epinephrine. The study indicated that high concentrations of cocaine may actually antagonize α-adrenoceptors, but these concentrations are not necessary in eliciting desired degrees of vasoconstriction in nasal blood vessels while being applied as a local anesthetic.

Original languageEnglish
Pages (from-to)245-248
Number of pages4
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume250
Issue number4
DOIs
Publication statusPublished - Jul 1993
Externally publishedYes

Fingerprint

Nasal Mucosa
Cocaine
Methoxamine
Nose
Blood Vessels
Local Anesthetics
Vasoconstriction
Adrenergic Receptors
Epinephrine
Norepinephrine
Pharmaceutical Preparations

Keywords

  • Cocaine
  • Human nasal mucosa
  • Sympathetic functions

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Effects of cocaine on human nasal mucosa. / Wang, S. H.; Wang, H. W.; Wang, J. Y.

In: European Archives of Oto-Rhino-Laryngology, Vol. 250, No. 4, 07.1993, p. 245-248.

Research output: Contribution to journalArticle

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