Effects of cimetidine on the metabolic disposition of isoniazid in rabbits

K. Y. Hsu, Y. S. Uang

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Abstract

Effects of cimetidine on the metabolic disposition of isoniazid (INH) were investigated in rabbits administered with 0.109 mmol kg-1 of either INH, acetylisoniazid (AcINH), isonicotinic acid (INA), sodium α-ketoglutarate isonicotinoyl hydrazone (INH-K) or sodium pyruvate isonicotinoyl hydrazone (INH-P). Oral cimetidine (50 mg kg-1 given 1 h prior to the other drugs significantly (p -1 kg-1. The mean formation fraction (F) of INA formed from the hydrolysis of INH and AcINH after administration of INH was significantly decreased (p

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalAsia Pacific Journal of Pharmacology
Volume4
Issue number4
Publication statusPublished - 1989

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ASJC Scopus subject areas

  • Pharmacology

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