Effects of cimetidine on the metabolic disposition of isoniazid in rabbits

K. Y. Hsu, Y. S. Uang

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Abstract

Effects of cimetidine on the metabolic disposition of isoniazid (INH) were investigated in rabbits administered with 0.109 mmol kg-1 of either INH, acetylisoniazid (AcINH), isonicotinic acid (INA), sodium α-ketoglutarate isonicotinoyl hydrazone (INH-K) or sodium pyruvate isonicotinoyl hydrazone (INH-P). Oral cimetidine (50 mg kg-1 given 1 h prior to the other drugs significantly (p -1 kg-1. The mean formation fraction (F) of INA formed from the hydrolysis of INH and AcINH after administration of INH was significantly decreased (p

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalAsia Pacific Journal of Pharmacology
Volume4
Issue number4
Publication statusPublished - 1989

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Isonicotinic Acids
Cimetidine
Isoniazid
Sodium
Rabbits
Hydrazones
Hydrolysis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of cimetidine on the metabolic disposition of isoniazid in rabbits. / Hsu, K. Y.; Uang, Y. S.

In: Asia Pacific Journal of Pharmacology, Vol. 4, No. 4, 1989, p. 307-314.

Research output: Contribution to journalArticle

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