Effects of chronic exposure to formaldehyde on micronucleus rate of bone marrow cells in male mice

Yunru Liu, Dee Yu, Sha Xiao

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Formaldehyde (FA) is the major volatile organic chemical (VOC) present in indoor air, and a constituent known to be associated with sick building syndrome. In the present study, mice were exposed to different concentrations of FA (0, 1, 10 mg/m3) through static inhalation for 2 hours per day for 20 weeks. The polychromatic erythrocytes/normochromatic erythrocyte (PCE/NCE) ratio and the micronucleus rates in bone marrow cells were detected. Data indicated that the PCE/NCE ratio in two FA exposure groups were statistically significant lower than the negative control group (P <0.05), and the micronucleus rate in two FA exposure groups were not significantly higher than the control group (P>0.05). These results suggest that chronic static inhalation of FA can reduce the ratio of PCE/NCE in the mice bone marrow, but the effects to the mice bone micronucleus rate are not sure.

Original languageEnglish
Pages (from-to)933-935
Number of pages3
JournalJournal of the Pakistan Medical Association
Volume67
Issue number6
Publication statusPublished - Jan 1 2017
Externally publishedYes

Keywords

  • Chronic exposure
  • Formaldehyde (FA)
  • Mice
  • Micronucleus

ASJC Scopus subject areas

  • Medicine(all)

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