Formaldehyde (FA) is the major volatile organic chemical (VOC) present in indoor air, and a constituent known to be associated with sick building syndrome. In the present study, mice were exposed to different concentrations of FA (0, 1, 10 mg/m3) through static inhalation for 2 hours per day for 20 weeks. The polychromatic erythrocytes/normochromatic erythrocyte (PCE/NCE) ratio and the micronucleus rates in bone marrow cells were detected. Data indicated that the PCE/NCE ratio in two FA exposure groups were statistically significant lower than the negative control group (P <0.05), and the micronucleus rate in two FA exposure groups were not significantly higher than the control group (P>0.05). These results suggest that chronic static inhalation of FA can reduce the ratio of PCE/NCE in the mice bone marrow, but the effects to the mice bone micronucleus rate are not sure.
|Number of pages||3|
|Journal||Journal of the Pakistan Medical Association|
|Publication status||Published - Jan 1 2017|
- Chronic exposure
- Formaldehyde (FA)
ASJC Scopus subject areas