Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress

Fuu Jen Tsai, Te Mao Li, Cheng Hang Ko, Chi Fung Cheng, Tsung Jung Ho, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Ju Pi Li, Shao Mei Huang, Jung Chun Lin, Chih Chien Lin, Wen Miin Liang, Ying Ju Lin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (P < 0.001, log-rank test). Among the top 10 CHMs, Jia-Wei-Xiao-Yao-San (JWXYS; 52.9%), Shu- Jing-Huo-Xue-Tang (SJHXT; 45.1%), and Ge-Gen-Tang (GGT; 43.7%) were the most common herbal formulas. Yan-Hu-Suo (48.1%), Ge-Gen (42.1%), and Huang-Qin (HQin; 40.1%) were the most common single herbs. CHM network analysis showed that JWXYS was the core CHM of cluster 1. JWXYS, DS, XF, and SZRT exhibited both of the reductions of H2O2-induced phosphorylation of p38 MAPK and p44/42 MAPK (Erk1/2) in human ARPE-19 retina cells. In cluster 2, SJHXT was the core CHM. SJHXT and NX showed both of the phosphorylation reductions. In cluster 3, GGT was the core CHM, and it reduced the phosphorylation of both MAPKs. In cluster 4, HQin was the core CHM, and it also reduced the phosphorylation of both MAPKs. Our study suggests that adjunctive CHM therapy may reduce diabetic retinopathy via antioxidant activity of the herbs and provides information on core CHM treatments for further scientific investigations or therapeutic interventions.

Original languageEnglish
Pages (from-to)63528-63550
Number of pages23
JournalOncotarget
Volume8
Issue number38
DOIs
Publication statusPublished - 2017

Fingerprint

Herbal Medicine
Diabetic Retinopathy
Type 2 Diabetes Mellitus
Retina
Oxidative Stress
Phosphorylation
Scutellaria baicalensis
Phytotherapy
Mitogen-Activated Protein Kinase 3
p38 Mitogen-Activated Protein Kinases
Blindness
Taiwan
Prescriptions
Therapeutics
Antioxidants

Keywords

  • Chinese herbal medicine
  • Diabetic retinopathy
  • Oxidative stress
  • Retina cells
  • Type 2 diabetes

ASJC Scopus subject areas

  • Oncology

Cite this

Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress. / Tsai, Fuu Jen; Li, Te Mao; Ko, Cheng Hang; Cheng, Chi Fung; Ho, Tsung Jung; Liu, Xiang; Tsang, Hsinyi; Lin, Ting Hsu; Liao, Chiu Chu; Li, Ju Pi; Huang, Shao Mei; Lin, Jung Chun; Lin, Chih Chien; Liang, Wen Miin; Lin, Ying Ju.

In: Oncotarget, Vol. 8, No. 38, 2017, p. 63528-63550.

Research output: Contribution to journalArticle

Tsai, FJ, Li, TM, Ko, CH, Cheng, CF, Ho, TJ, Liu, X, Tsang, H, Lin, TH, Liao, CC, Li, JP, Huang, SM, Lin, JC, Lin, CC, Liang, WM & Lin, YJ 2017, 'Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress', Oncotarget, vol. 8, no. 38, pp. 63528-63550. https://doi.org/10.18632/oncotarget.18846
Tsai, Fuu Jen ; Li, Te Mao ; Ko, Cheng Hang ; Cheng, Chi Fung ; Ho, Tsung Jung ; Liu, Xiang ; Tsang, Hsinyi ; Lin, Ting Hsu ; Liao, Chiu Chu ; Li, Ju Pi ; Huang, Shao Mei ; Lin, Jung Chun ; Lin, Chih Chien ; Liang, Wen Miin ; Lin, Ying Ju. / Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress. In: Oncotarget. 2017 ; Vol. 8, No. 38. pp. 63528-63550.
@article{0fb8ecdd21fd475d910356813ec95b0f,
title = "Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress",
abstract = "Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (P < 0.001, log-rank test). Among the top 10 CHMs, Jia-Wei-Xiao-Yao-San (JWXYS; 52.9{\%}), Shu- Jing-Huo-Xue-Tang (SJHXT; 45.1{\%}), and Ge-Gen-Tang (GGT; 43.7{\%}) were the most common herbal formulas. Yan-Hu-Suo (48.1{\%}), Ge-Gen (42.1{\%}), and Huang-Qin (HQin; 40.1{\%}) were the most common single herbs. CHM network analysis showed that JWXYS was the core CHM of cluster 1. JWXYS, DS, XF, and SZRT exhibited both of the reductions of H2O2-induced phosphorylation of p38 MAPK and p44/42 MAPK (Erk1/2) in human ARPE-19 retina cells. In cluster 2, SJHXT was the core CHM. SJHXT and NX showed both of the phosphorylation reductions. In cluster 3, GGT was the core CHM, and it reduced the phosphorylation of both MAPKs. In cluster 4, HQin was the core CHM, and it also reduced the phosphorylation of both MAPKs. Our study suggests that adjunctive CHM therapy may reduce diabetic retinopathy via antioxidant activity of the herbs and provides information on core CHM treatments for further scientific investigations or therapeutic interventions.",
keywords = "Chinese herbal medicine, Diabetic retinopathy, Oxidative stress, Retina cells, Type 2 diabetes",
author = "Tsai, {Fuu Jen} and Li, {Te Mao} and Ko, {Cheng Hang} and Cheng, {Chi Fung} and Ho, {Tsung Jung} and Xiang Liu and Hsinyi Tsang and Lin, {Ting Hsu} and Liao, {Chiu Chu} and Li, {Ju Pi} and Huang, {Shao Mei} and Lin, {Jung Chun} and Lin, {Chih Chien} and Liang, {Wen Miin} and Lin, {Ying Ju}",
year = "2017",
doi = "10.18632/oncotarget.18846",
language = "English",
volume = "8",
pages = "63528--63550",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "38",

}

TY - JOUR

T1 - Effects of Chinese herbal medicines on the occurrence of diabetic retinopathy in type 2 diabetes patients and protection of ARPE-19 retina cells by inhibiting oxidative stress

AU - Tsai, Fuu Jen

AU - Li, Te Mao

AU - Ko, Cheng Hang

AU - Cheng, Chi Fung

AU - Ho, Tsung Jung

AU - Liu, Xiang

AU - Tsang, Hsinyi

AU - Lin, Ting Hsu

AU - Liao, Chiu Chu

AU - Li, Ju Pi

AU - Huang, Shao Mei

AU - Lin, Jung Chun

AU - Lin, Chih Chien

AU - Liang, Wen Miin

AU - Lin, Ying Ju

PY - 2017

Y1 - 2017

N2 - Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (P < 0.001, log-rank test). Among the top 10 CHMs, Jia-Wei-Xiao-Yao-San (JWXYS; 52.9%), Shu- Jing-Huo-Xue-Tang (SJHXT; 45.1%), and Ge-Gen-Tang (GGT; 43.7%) were the most common herbal formulas. Yan-Hu-Suo (48.1%), Ge-Gen (42.1%), and Huang-Qin (HQin; 40.1%) were the most common single herbs. CHM network analysis showed that JWXYS was the core CHM of cluster 1. JWXYS, DS, XF, and SZRT exhibited both of the reductions of H2O2-induced phosphorylation of p38 MAPK and p44/42 MAPK (Erk1/2) in human ARPE-19 retina cells. In cluster 2, SJHXT was the core CHM. SJHXT and NX showed both of the phosphorylation reductions. In cluster 3, GGT was the core CHM, and it reduced the phosphorylation of both MAPKs. In cluster 4, HQin was the core CHM, and it also reduced the phosphorylation of both MAPKs. Our study suggests that adjunctive CHM therapy may reduce diabetic retinopathy via antioxidant activity of the herbs and provides information on core CHM treatments for further scientific investigations or therapeutic interventions.

AB - Diabetic retinopathy is a microvascular complication of type 2 diabetes and the leading cause of acquired blindness. In Taiwan, Chinese herbal medicine (CHM) is a popular adjunctive therapy. In this study, we investigated the CHM prescription patterns and their effects. We identified 23,701 subjects with type 2 diabetes in a database, and after matching for age and gender, 6,948 patients each were assigned to CHM and non-CHM groups. In the female subgroups, the cumulative retinopathy probability was lower for the CHM users than that for the CHM non-users (P < 0.001, log-rank test). Among the top 10 CHMs, Jia-Wei-Xiao-Yao-San (JWXYS; 52.9%), Shu- Jing-Huo-Xue-Tang (SJHXT; 45.1%), and Ge-Gen-Tang (GGT; 43.7%) were the most common herbal formulas. Yan-Hu-Suo (48.1%), Ge-Gen (42.1%), and Huang-Qin (HQin; 40.1%) were the most common single herbs. CHM network analysis showed that JWXYS was the core CHM of cluster 1. JWXYS, DS, XF, and SZRT exhibited both of the reductions of H2O2-induced phosphorylation of p38 MAPK and p44/42 MAPK (Erk1/2) in human ARPE-19 retina cells. In cluster 2, SJHXT was the core CHM. SJHXT and NX showed both of the phosphorylation reductions. In cluster 3, GGT was the core CHM, and it reduced the phosphorylation of both MAPKs. In cluster 4, HQin was the core CHM, and it also reduced the phosphorylation of both MAPKs. Our study suggests that adjunctive CHM therapy may reduce diabetic retinopathy via antioxidant activity of the herbs and provides information on core CHM treatments for further scientific investigations or therapeutic interventions.

KW - Chinese herbal medicine

KW - Diabetic retinopathy

KW - Oxidative stress

KW - Retina cells

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85029806410&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029806410&partnerID=8YFLogxK

U2 - 10.18632/oncotarget.18846

DO - 10.18632/oncotarget.18846

M3 - Article

AN - SCOPUS:85029806410

VL - 8

SP - 63528

EP - 63550

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 38

ER -