Effects of chemically defined tannins on Poly(ADP-ribose) glycohydrolase activity

Y. J. Tsai, H. Abe, H. Maruta, T. Hatano, H. Nishina, H. Sakagami, T. Okuda, S. I. Tanuma

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Three classes of chemically defined tannins, gallotannins, ellagitannins and condensed tannins were examined for their inhibitory activities against purified poly(ADP-ribose) glycohydrolase. Ellagitannins showed higher inhibitory activities than gallotannins. In contrant, condensed tannins, which consist of an epicathechin gallate (ECG) oligomer without a glucose core were not appreciably inhibitory. Kinetic analysis revealed that the inhibition of ellagitannins was competitive with respect to the substrate poly(ADP-ribose), whereas gallotannins exhibited mixed-type inhibition. These results suggest that conjugation with glucose of hexahydroxydiphenoyl (HHDP) group, which is a unique component of ellagitannins, potentiated the inhibitory activity, and that the structure of ellagitannins may have a functional domain which competes with poly(ADP-ribose) on the poly(ADP-ribose) glycohydrolase molecule.

Original languageEnglish
Pages (from-to)889-897
Number of pages9
JournalBiochemistry International
Volume24
Issue number5
Publication statusPublished - 1991

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Hydrolyzable Tannins
Tannins
Poly Adenosine Diphosphate Ribose
Proanthocyanidins
Glucose
poly ADP-ribose glycohydrolase
Oligomers
Molecules
Kinetics

ASJC Scopus subject areas

  • Biochemistry

Cite this

Tsai, Y. J., Abe, H., Maruta, H., Hatano, T., Nishina, H., Sakagami, H., ... Tanuma, S. I. (1991). Effects of chemically defined tannins on Poly(ADP-ribose) glycohydrolase activity. Biochemistry International, 24(5), 889-897.

Effects of chemically defined tannins on Poly(ADP-ribose) glycohydrolase activity. / Tsai, Y. J.; Abe, H.; Maruta, H.; Hatano, T.; Nishina, H.; Sakagami, H.; Okuda, T.; Tanuma, S. I.

In: Biochemistry International, Vol. 24, No. 5, 1991, p. 889-897.

Research output: Contribution to journalArticle

Tsai, YJ, Abe, H, Maruta, H, Hatano, T, Nishina, H, Sakagami, H, Okuda, T & Tanuma, SI 1991, 'Effects of chemically defined tannins on Poly(ADP-ribose) glycohydrolase activity', Biochemistry International, vol. 24, no. 5, pp. 889-897.
Tsai YJ, Abe H, Maruta H, Hatano T, Nishina H, Sakagami H et al. Effects of chemically defined tannins on Poly(ADP-ribose) glycohydrolase activity. Biochemistry International. 1991;24(5):889-897.
Tsai, Y. J. ; Abe, H. ; Maruta, H. ; Hatano, T. ; Nishina, H. ; Sakagami, H. ; Okuda, T. ; Tanuma, S. I. / Effects of chemically defined tannins on Poly(ADP-ribose) glycohydrolase activity. In: Biochemistry International. 1991 ; Vol. 24, No. 5. pp. 889-897.
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