攝取類胡蘿蔔素對雄性倉鼠口腔癌化與抗氧化酵素之影響

Translated title of the contribution: Effects of carotenoid consumption on oral carcinogenesis and antioxidative enzymes in male hamsters

H. Chien, S. Y. Huang, Y. H. Lin, Y. H. Shieh, Ming-Che Hsieh, M. J. Shieh

Research output: Contribution to journalArticle

Abstract

This study investigated the effects of consumption of various carotenoids on oral carcinogenesis and the activity of antioxidative enzymes in male hamsters. In the first 4 weeks, the right buccal pouch of each animal was daubed with 9, 10-dimethyl-1, 2-benz-anthracene (DMBA) three times a week, and in the following 12 weeks the right buccal pouch was daubed with betel quid extract (BQE) and the rats were fed different experimental diets. Diets of the experimental groups were individually supplemented with 0.1% of Β-carotene, lycopene, lutein, canthaxanthin, or equal amount of these four carotenoids (0.025% each) during the following 12 weeks. The results indicate that plasma and liver carotenoid levels of experimental groups were significantly higher than those of the control group (p <0.05). Red blood cell (RBC) superoxide dismutase (SOD) activities of the lycopene and mixture groups were significantly lower than the control group, as was liver SOD activity of the canthaxanthin and mixture groups. Liver glutathione peroxidase (GPx) activities of the lutein, canthaxanthin, and mixture groups were significantly lower than that of the control group; however there was no difference between the activity of RBC GPx in each group. The plasma malondialdehyde (MDA) level in the mixture group was significantly lower than in the control group (p <0.05); furthermore, hepatic MDA levels of the carotenoid treated groups were all significantly lower than that of the control group (p <0.05). The number and volume of the tumor burden of the experimental groups were significantly lower than those of the control group. In conclusion, carotenoids provide an inhibitory capability on BQE-induced hamster oral carcinogenesis. The carotenoids significantly reduced the plasma and liver MDA levels and decreased the BQE-induced tumor burden in hamsters, especially in groups treated with lycopene, canthaxanthin, and a mixture of carotenoids.

Original languageTraditional Chinese
Pages (from-to)171-180
Number of pages10
JournalNutritional Sciences Journal
Volume26
Issue number3
Publication statusPublished - 2001

Fingerprint

Carotenoids
hamsters
Cricetinae
carcinogenesis
mouth
Carcinogenesis
carotenoids
Canthaxanthin
canthaxanthin
betel
Enzymes
enzymes
Control Groups
lycopene
liver
malondialdehyde
Malondialdehyde
Liver
Lutein
pouches

Keywords

  • Betel quid extract
  • Buccal pouch carcinoma
  • Carotenoids
  • Hamster

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

攝取類胡蘿蔔素對雄性倉鼠口腔癌化與抗氧化酵素之影響. / Chien, H.; Huang, S. Y.; Lin, Y. H.; Shieh, Y. H.; Hsieh, Ming-Che; Shieh, M. J.

In: Nutritional Sciences Journal, Vol. 26, No. 3, 2001, p. 171-180.

Research output: Contribution to journalArticle

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abstract = "This study investigated the effects of consumption of various carotenoids on oral carcinogenesis and the activity of antioxidative enzymes in male hamsters. In the first 4 weeks, the right buccal pouch of each animal was daubed with 9, 10-dimethyl-1, 2-benz-anthracene (DMBA) three times a week, and in the following 12 weeks the right buccal pouch was daubed with betel quid extract (BQE) and the rats were fed different experimental diets. Diets of the experimental groups were individually supplemented with 0.1{\%} of Β-carotene, lycopene, lutein, canthaxanthin, or equal amount of these four carotenoids (0.025{\%} each) during the following 12 weeks. The results indicate that plasma and liver carotenoid levels of experimental groups were significantly higher than those of the control group (p <0.05). Red blood cell (RBC) superoxide dismutase (SOD) activities of the lycopene and mixture groups were significantly lower than the control group, as was liver SOD activity of the canthaxanthin and mixture groups. Liver glutathione peroxidase (GPx) activities of the lutein, canthaxanthin, and mixture groups were significantly lower than that of the control group; however there was no difference between the activity of RBC GPx in each group. The plasma malondialdehyde (MDA) level in the mixture group was significantly lower than in the control group (p <0.05); furthermore, hepatic MDA levels of the carotenoid treated groups were all significantly lower than that of the control group (p <0.05). The number and volume of the tumor burden of the experimental groups were significantly lower than those of the control group. In conclusion, carotenoids provide an inhibitory capability on BQE-induced hamster oral carcinogenesis. The carotenoids significantly reduced the plasma and liver MDA levels and decreased the BQE-induced tumor burden in hamsters, especially in groups treated with lycopene, canthaxanthin, and a mixture of carotenoids.",
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AU - Chien, H.

AU - Huang, S. Y.

AU - Lin, Y. H.

AU - Shieh, Y. H.

AU - Hsieh, Ming-Che

AU - Shieh, M. J.

PY - 2001

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N2 - This study investigated the effects of consumption of various carotenoids on oral carcinogenesis and the activity of antioxidative enzymes in male hamsters. In the first 4 weeks, the right buccal pouch of each animal was daubed with 9, 10-dimethyl-1, 2-benz-anthracene (DMBA) three times a week, and in the following 12 weeks the right buccal pouch was daubed with betel quid extract (BQE) and the rats were fed different experimental diets. Diets of the experimental groups were individually supplemented with 0.1% of Β-carotene, lycopene, lutein, canthaxanthin, or equal amount of these four carotenoids (0.025% each) during the following 12 weeks. The results indicate that plasma and liver carotenoid levels of experimental groups were significantly higher than those of the control group (p <0.05). Red blood cell (RBC) superoxide dismutase (SOD) activities of the lycopene and mixture groups were significantly lower than the control group, as was liver SOD activity of the canthaxanthin and mixture groups. Liver glutathione peroxidase (GPx) activities of the lutein, canthaxanthin, and mixture groups were significantly lower than that of the control group; however there was no difference between the activity of RBC GPx in each group. The plasma malondialdehyde (MDA) level in the mixture group was significantly lower than in the control group (p <0.05); furthermore, hepatic MDA levels of the carotenoid treated groups were all significantly lower than that of the control group (p <0.05). The number and volume of the tumor burden of the experimental groups were significantly lower than those of the control group. In conclusion, carotenoids provide an inhibitory capability on BQE-induced hamster oral carcinogenesis. The carotenoids significantly reduced the plasma and liver MDA levels and decreased the BQE-induced tumor burden in hamsters, especially in groups treated with lycopene, canthaxanthin, and a mixture of carotenoids.

AB - This study investigated the effects of consumption of various carotenoids on oral carcinogenesis and the activity of antioxidative enzymes in male hamsters. In the first 4 weeks, the right buccal pouch of each animal was daubed with 9, 10-dimethyl-1, 2-benz-anthracene (DMBA) three times a week, and in the following 12 weeks the right buccal pouch was daubed with betel quid extract (BQE) and the rats were fed different experimental diets. Diets of the experimental groups were individually supplemented with 0.1% of Β-carotene, lycopene, lutein, canthaxanthin, or equal amount of these four carotenoids (0.025% each) during the following 12 weeks. The results indicate that plasma and liver carotenoid levels of experimental groups were significantly higher than those of the control group (p <0.05). Red blood cell (RBC) superoxide dismutase (SOD) activities of the lycopene and mixture groups were significantly lower than the control group, as was liver SOD activity of the canthaxanthin and mixture groups. Liver glutathione peroxidase (GPx) activities of the lutein, canthaxanthin, and mixture groups were significantly lower than that of the control group; however there was no difference between the activity of RBC GPx in each group. The plasma malondialdehyde (MDA) level in the mixture group was significantly lower than in the control group (p <0.05); furthermore, hepatic MDA levels of the carotenoid treated groups were all significantly lower than that of the control group (p <0.05). The number and volume of the tumor burden of the experimental groups were significantly lower than those of the control group. In conclusion, carotenoids provide an inhibitory capability on BQE-induced hamster oral carcinogenesis. The carotenoids significantly reduced the plasma and liver MDA levels and decreased the BQE-induced tumor burden in hamsters, especially in groups treated with lycopene, canthaxanthin, and a mixture of carotenoids.

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KW - 檳榔嚼塊萃取物

KW - 類胡蘿蔔素

KW - 倉鼠

KW - 口腔頰囊癌

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