Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects: A randomize-controlled trial

Hsiu Chuan Lee, Wen Yi Cheng, Yi Hao Hsu, Hsiu Yueh Su, Brian E T G Huang, Yen-Kuang Lin, Wing P. Chan, Chien-Tien Su, Shih-Yi Huang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Metabolic syndrome (MetS) increases the risk of type 2 DM and cardiovascular disease. We here evaluated the effects of a calorie-restriction diet with 2.13 g/day n-3 long-chain polyunsaturated fatty acid supplementation in MetS patients. The 188 participants were randomly assigned one of four calorie-restriction diets for 12 weeks: calorie-restriction (n = 44), calorie-restriction meal replacement (n = 45), calorie-restriction with fish oil (n = 44), or calorie-restriction meal replacement with fish oil (n = 44); 179 participants completed the trial. After treatment, all groups had significant reduction in waist circumference, blood pressure, and cardiometabolic parameters. Results indicate that long-chain polyunsaturated fatty acid (LC-PUFA) supplementation under calorie-restriction exert beneficial effects on metabolic parameters.

Original languageEnglish
Pages (from-to)929-940
Number of pages12
JournalJournal of Functional Foods
Volume19
DOIs
Publication statusPublished - 2015

Keywords

  • Metabolic syndrome
  • N-3 long-chain polyunsaturated fatty acids
  • N-6/n-3 ratio

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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