Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects: A randomize-controlled trial

Hsiu Chuan Lee, Wen Yi Cheng, Yi Hao Hsu, Hsiu Yueh Su, Brian E T G Huang, Yen-Kuang Lin, Wing P. Chan, Chien-Tien Su, Shih-Yi Huang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Metabolic syndrome (MetS) increases the risk of type 2 DM and cardiovascular disease. We here evaluated the effects of a calorie-restriction diet with 2.13 g/day n-3 long-chain polyunsaturated fatty acid supplementation in MetS patients. The 188 participants were randomly assigned one of four calorie-restriction diets for 12 weeks: calorie-restriction (n = 44), calorie-restriction meal replacement (n = 45), calorie-restriction with fish oil (n = 44), or calorie-restriction meal replacement with fish oil (n = 44); 179 participants completed the trial. After treatment, all groups had significant reduction in waist circumference, blood pressure, and cardiometabolic parameters. Results indicate that long-chain polyunsaturated fatty acid (LC-PUFA) supplementation under calorie-restriction exert beneficial effects on metabolic parameters.

Original languageEnglish
Pages (from-to)929-940
Number of pages12
JournalJournal of Functional Foods
Volume19
DOIs
Publication statusPublished - 2015

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long chain polyunsaturated fatty acids
Fish Oils
metabolic syndrome
Unsaturated Fatty Acids
fish oils
Meals
Diet
waist circumference
Waist Circumference
diet
cardiovascular diseases
blood pressure
Cardiovascular Diseases
Blood Pressure
Therapeutics

Keywords

  • Metabolic syndrome
  • N-3 long-chain polyunsaturated fatty acids
  • N-6/n-3 ratio

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects : A randomize-controlled trial. / Lee, Hsiu Chuan; Cheng, Wen Yi; Hsu, Yi Hao; Su, Hsiu Yueh; Huang, Brian E T G; Lin, Yen-Kuang; Chan, Wing P.; Su, Chien-Tien; Huang, Shih-Yi.

In: Journal of Functional Foods, Vol. 19, 2015, p. 929-940.

Research output: Contribution to journalArticle

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