Effects of calorie restriction plus fish oil supplementation on abnormal metabolic characteristics and the iron status of middle-aged obese women

Fasty Arum Utami, Hsiu Chuan Lee, Chien Tien Su, Yu Ru Guo, Yu Tang Tung, Shih Yi Huang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The increasing prevalence of obesity and sedentary lifestyles has led to a higher incidence of metabolic syndrome (MetS) worldwide as well as in Taiwan. Middle-aged women are at a greater risk of MetS, type 2 diabetes, and cardiovascular disease than men because they have more subcutaneous fat and larger waist circumferences compared with men with equal visceral fat levels. In this study, we investigated the effects of calorie restriction (CR) and fish oil supplementation (CRF) on middle-aged Taiwanese women with MetS. An open-label, parallel-arm, controlled trial was conducted for 12 weeks. A total of 75 eligible participants were randomly assigned to the CR or CRF group. Both the dietary intervention groups were further divided into two age groups: ≤45 and >45 years. Changes in MetS severity, inflammatory status, iron status, and red blood cell fatty acid profile were evaluated. A total of 71 participants completed the trial. Both dietary interventions significantly ameliorated MetS and improved the participants' inflammatory status. CR significantly increased the total iron-binding capacity (TIBC) whereas CRF increased hepcidin levels in women aged >45 years. Furthermore, CRF significantly increased the n-6/n-3 and arachidonic acid/docosahexaenoic acid ratios. Both interventions improved the anthropometric and MetS characteristics, including body weight, blood glucose and triglyceride levels, and the score of the homeostasis model assessment of insulin resistance and quantitative insulin sensitivity check index. In conclusion, the 12-week dietary interventions improved the abnormal metabolic status of middle-aged obese women. CRF was demonstrated to be more effective in ameliorating postprandial glucose level and TIBC in women aged >45 years than in those aged ≤45 years.

Original languageEnglish
Pages (from-to)1152-1162
Number of pages11
JournalFood and Function
Volume9
Issue number2
DOIs
Publication statusPublished - Feb 1 2018

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middle-aged adults
Fish Oils
metabolic syndrome
fish oils
Iron
iron
binding capacity
insulin resistance
Insulin Resistance
Hepcidins
Sedentary Lifestyle
visceral fat
Intra-Abdominal Fat
Docosahexaenoic Acids
Subcutaneous Fat
waist circumference
subcutaneous fat
Waist Circumference
docosahexaenoic acid
Taiwan

ASJC Scopus subject areas

  • Food Science

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Effects of calorie restriction plus fish oil supplementation on abnormal metabolic characteristics and the iron status of middle-aged obese women. / Utami, Fasty Arum; Lee, Hsiu Chuan; Su, Chien Tien; Guo, Yu Ru; Tung, Yu Tang; Huang, Shih Yi.

In: Food and Function, Vol. 9, No. 2, 01.02.2018, p. 1152-1162.

Research output: Contribution to journalArticle

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