TY - JOUR
T1 - Effects of brain epinephrine depletion on thermoregulation, reflex bradycardia, and motor activity in rats
AU - Tsai, Shin Han
AU - Shih, Chun Jen
AU - Lin, Mao Tsun
N1 - Funding Information:
Abbreviations: PNMT-phenylethanolamine N-methyltransferase, EPI-epinephrine, CONH-2-cyclooctyi-2-hydroxyethyl-amine, CUNH--I-aminomethylcycloundecanol, DCMB-2,3dichloro-o-methylbenzylamine, SKF64139-7,8dichloro-1,2,3,4-tetrahydroisoquinoline. ’ This work was supported by grants from the National Science Council (Taipei, Taiwan, Republic of China). We thank Dr. Nina Y. Liang (Department of Pharmacology and Toxicology, University of Kansas) for supply of PNMT inhibitors used in this study. Please address correspondence to Dr. S. H. Tsai, National Defense Medical Center, P.O. Box 8244, Taipei, Taiwan, ROC.
PY - 1985/3
Y1 - 1985/3
N2 - Two hours after i.p. administration of 2-cyclooctyl-2-hydroxyethylamine (CONH), 1-aminomethylcycloundecanol (CUNH), 2,3-dichloro-α-methylbenzylamine (DCMB), or 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF64139), the hypothalamic and brain stem epinephrine (EPI) contents of rat brain were decreased. Depletions of brain EPI with these phenylethanolamine N-methyltransferase (PNMT) inhibitors reduced the rectal temperatures of rats at ambient temperatures of 8 and 22°C. The hypothermia in response to these PNMT inhibitors was due to decreased metabolism and cutaneous vasodilatation. The locomotor stimulant responses induced by thyrotropin-releasing hormone were also reduced by administration of any one of these PNMT inhibitors. On the other hand, acute administration of any of these PNMT inhibitors enhanced the reflex bradycardia induced by i.v. infusion of EPI. The data suggest that brain (particularly the hypothalamus and brain stem) EPI-containing neurons are involved in the regulation of body temperature, reflex bradycardia, and motor performance in the rat.
AB - Two hours after i.p. administration of 2-cyclooctyl-2-hydroxyethylamine (CONH), 1-aminomethylcycloundecanol (CUNH), 2,3-dichloro-α-methylbenzylamine (DCMB), or 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (SKF64139), the hypothalamic and brain stem epinephrine (EPI) contents of rat brain were decreased. Depletions of brain EPI with these phenylethanolamine N-methyltransferase (PNMT) inhibitors reduced the rectal temperatures of rats at ambient temperatures of 8 and 22°C. The hypothermia in response to these PNMT inhibitors was due to decreased metabolism and cutaneous vasodilatation. The locomotor stimulant responses induced by thyrotropin-releasing hormone were also reduced by administration of any one of these PNMT inhibitors. On the other hand, acute administration of any of these PNMT inhibitors enhanced the reflex bradycardia induced by i.v. infusion of EPI. The data suggest that brain (particularly the hypothalamus and brain stem) EPI-containing neurons are involved in the regulation of body temperature, reflex bradycardia, and motor performance in the rat.
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U2 - 10.1016/0014-4886(85)90173-6
DO - 10.1016/0014-4886(85)90173-6
M3 - Article
C2 - 3972046
AN - SCOPUS:0021911839
SN - 0014-4886
VL - 87
SP - 428
EP - 438
JO - Neurodegeneration
JF - Neurodegeneration
IS - 3
ER -