Abstract
Purpose: The aim of this study was to investigate the effects of bimatoprost 0.03% on ocular hemodynamics in patients with normal tension glaucoma (NTG). Methods: Twenty-two (22) patients with NTG were consecutively recruited. After basic eye examination and diurnal intraocular pressure (IOP) measurement, color Doppler imaging was used to measure the peak systolic and end diastolic velocities and resistive index of the central retinal, lateral posterior ciliary, and medial posterior ciliary arteries. Patients received bimatoprost 0.03% for 4 weeks, and these measurements were then repeated. The worse eye of each NTG patient was used in the statistical analysis. Results: Bimatoprost 0.03% significantly reduced mean IOP from 15.1 ± 3.8 mmHg at baseline to 12.0 ±2.9 mmHg after treatment in our sample of NTG patients (P < 0.001). No significant changes in blood velocities or resistance indices were observed in the retrobulbar vessels after the 4-week treatment Conclusions: Topical bimatoprost 0.03% significantly reduced IOP in our NTG patients without causing significant hemodynamic changes in the retrobulbar vessels.
| Original language | English |
|---|---|
| Pages (from-to) | 188-193 |
| Number of pages | 6 |
| Journal | Journal of Ocular Pharmacology and Therapeutics |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 1 2006 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ophthalmology
- Pharmacology
- Pharmacology (medical)
Cite this
Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma. / Chen, Mei Ju; Cheng, Ching Yu; Chen, Yen Cheng; Chou, Ching Kuang; Hsu, Wen-Ming.
In: Journal of Ocular Pharmacology and Therapeutics, Vol. 22, No. 3, 01.06.2006, p. 188-193.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma
AU - Chen, Mei Ju
AU - Cheng, Ching Yu
AU - Chen, Yen Cheng
AU - Chou, Ching Kuang
AU - Hsu, Wen-Ming
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Purpose: The aim of this study was to investigate the effects of bimatoprost 0.03% on ocular hemodynamics in patients with normal tension glaucoma (NTG). Methods: Twenty-two (22) patients with NTG were consecutively recruited. After basic eye examination and diurnal intraocular pressure (IOP) measurement, color Doppler imaging was used to measure the peak systolic and end diastolic velocities and resistive index of the central retinal, lateral posterior ciliary, and medial posterior ciliary arteries. Patients received bimatoprost 0.03% for 4 weeks, and these measurements were then repeated. The worse eye of each NTG patient was used in the statistical analysis. Results: Bimatoprost 0.03% significantly reduced mean IOP from 15.1 ± 3.8 mmHg at baseline to 12.0 ±2.9 mmHg after treatment in our sample of NTG patients (P < 0.001). No significant changes in blood velocities or resistance indices were observed in the retrobulbar vessels after the 4-week treatment Conclusions: Topical bimatoprost 0.03% significantly reduced IOP in our NTG patients without causing significant hemodynamic changes in the retrobulbar vessels.
AB - Purpose: The aim of this study was to investigate the effects of bimatoprost 0.03% on ocular hemodynamics in patients with normal tension glaucoma (NTG). Methods: Twenty-two (22) patients with NTG were consecutively recruited. After basic eye examination and diurnal intraocular pressure (IOP) measurement, color Doppler imaging was used to measure the peak systolic and end diastolic velocities and resistive index of the central retinal, lateral posterior ciliary, and medial posterior ciliary arteries. Patients received bimatoprost 0.03% for 4 weeks, and these measurements were then repeated. The worse eye of each NTG patient was used in the statistical analysis. Results: Bimatoprost 0.03% significantly reduced mean IOP from 15.1 ± 3.8 mmHg at baseline to 12.0 ±2.9 mmHg after treatment in our sample of NTG patients (P < 0.001). No significant changes in blood velocities or resistance indices were observed in the retrobulbar vessels after the 4-week treatment Conclusions: Topical bimatoprost 0.03% significantly reduced IOP in our NTG patients without causing significant hemodynamic changes in the retrobulbar vessels.
UR - http://www.scopus.com/inward/record.url?scp=33745875027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745875027&partnerID=8YFLogxK
U2 - 10.1089/jop.2006.22.188
DO - 10.1089/jop.2006.22.188
M3 - Article
C2 - 16808680
AN - SCOPUS:33745875027
VL - 22
SP - 188
EP - 193
JO - Journal of Ocular Pharmacology and Therapeutics
JF - Journal of Ocular Pharmacology and Therapeutics
SN - 1080-7683
IS - 3
ER -