Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma

Mei Ju Chen, Ching Yu Cheng, Yen Cheng Chen, Ching Kuang Chou, Wen-Ming Hsu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: The aim of this study was to investigate the effects of bimatoprost 0.03% on ocular hemodynamics in patients with normal tension glaucoma (NTG). Methods: Twenty-two (22) patients with NTG were consecutively recruited. After basic eye examination and diurnal intraocular pressure (IOP) measurement, color Doppler imaging was used to measure the peak systolic and end diastolic velocities and resistive index of the central retinal, lateral posterior ciliary, and medial posterior ciliary arteries. Patients received bimatoprost 0.03% for 4 weeks, and these measurements were then repeated. The worse eye of each NTG patient was used in the statistical analysis. Results: Bimatoprost 0.03% significantly reduced mean IOP from 15.1 ± 3.8 mmHg at baseline to 12.0 ±2.9 mmHg after treatment in our sample of NTG patients (P < 0.001). No significant changes in blood velocities or resistance indices were observed in the retrobulbar vessels after the 4-week treatment Conclusions: Topical bimatoprost 0.03% significantly reduced IOP in our NTG patients without causing significant hemodynamic changes in the retrobulbar vessels.

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalJournal of Ocular Pharmacology and Therapeutics
Volume22
Issue number3
DOIs
Publication statusPublished - Jun 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

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