Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults

Kuang Chung Shih, Anthony J. Janckila, Wei Jei Lee, Yu Ching Chou, Chun Jui Huang, Ching Fai Kwok, Low Tone Ho, Tsu Yi Chao

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. Methods: Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12. months postoperatively. Results: Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3. months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12. months in non-DM group, while improving significantly at 6 and 12. months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12. months in non-DM group and 12. months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3. months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6. months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12. months postoperatively without significant changes in CRP and IL-6. Conclusion: Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalClinica Chimica Acta
Volume453
DOIs
Publication statusPublished - Jan 30 2016

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Bariatrics
Anthropometry
Acid Phosphatase
Metabolism
Surgery
Weight Loss
Cytokines
Insulin Resistance
Glucose
Bariatric Surgery
Insulin
Serum
C-Reactive Protein
Interleukin-6
Homeostasis
LDL Cholesterol
Biomarkers
Lipids
Tartrate-Resistant Acid Phosphatase
tartaric acid

Keywords

  • Bariatric surgery
  • Diabetes mellitus
  • Inflammatory cytokine
  • Insulin resistance
  • Metabolic syndrome
  • Tartrate-resistant acid phosphatase 5a

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults. / Shih, Kuang Chung; Janckila, Anthony J.; Lee, Wei Jei; Chou, Yu Ching; Huang, Chun Jui; Kwok, Ching Fai; Ho, Low Tone; Chao, Tsu Yi.

In: Clinica Chimica Acta, Vol. 453, 30.01.2016, p. 197-202.

Research output: Contribution to journalArticle

Shih, Kuang Chung ; Janckila, Anthony J. ; Lee, Wei Jei ; Chou, Yu Ching ; Huang, Chun Jui ; Kwok, Ching Fai ; Ho, Low Tone ; Chao, Tsu Yi. / Effects of bariatric weight loss surgery on glucose metabolism, inflammatory cytokines, and serum tartrate-resistant acid phosphatase 5a in obese Chinese adults. In: Clinica Chimica Acta. 2016 ; Vol. 453. pp. 197-202.
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AU - Chou, Yu Ching

AU - Huang, Chun Jui

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AU - Ho, Low Tone

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N2 - Background: We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. Methods: Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12. months postoperatively. Results: Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3. months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12. months in non-DM group, while improving significantly at 6 and 12. months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12. months in non-DM group and 12. months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3. months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6. months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12. months postoperatively without significant changes in CRP and IL-6. Conclusion: Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.

AB - Background: We determined effects of bariatric weight loss surgery on serum tartrate-resistant acid phosphatase 5a (TRACP 5a), inflammatory cytokines and glucose homeostasis in severely obese Chinese adults. Methods: Severely obese adults undergoing bariatric surgery were recruited. Anthropometry, insulin resistance (IR), inflammatory markers and serum TRACP 5a were measured at baseline and 3, 6 and 12. months postoperatively. Results: Data of 93 patients, including 69 non-diabetic (non-DM group) and 24 diabetic (DM group), were analyzed. Anthropometry decreased significantly at 3. months postoperatively in both groups; low-density lipoprotein cholesterol decreased obviously at 3, 6 and 12. months in non-DM group, while improving significantly at 6 and 12. months in DM group. Homeostasis model assessment for IR (HOMA-IR) improved significantly at 3, 6 and 12. months in non-DM group and 12. months in DM group. In DM group, C-reactive protein (CRP) decreased significantly at 3. months postoperatively and inflammatory markers interleukin-6 (IL-6) and TRACP 5a improved at 6. months postoperatively; in non-DM group, serum TRACP 5a decreased obviously at 12. months postoperatively without significant changes in CRP and IL-6. Conclusion: Weight reduction by bariatric surgery decreases anthropometry, IR, lipids and inflammatory markers in severely obese Chinese adults.

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