Effects of antibacterial nanostructured composite films on vascular stents

Hemodynamic behaviors, microstructural characteristics, and biomechanical properties

Han Yi Cheng, Wen Tien Hsiao, Li Hsiang Lin, Ya Ju Hsu, Andi Wardihan Sinrang, Keng Liang Ou

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of this research was to investigate stresses resulting from different thicknesses and compositions of hydrogenated Cu-incorporated diamond-like carbon (a-C:H/Cu) films at the interface between vascular stent and the artery using three-dimensional reversed finite element models (FEMs). Blood flow velocity variation in vessels with plaques was examined by angiography, and the a-C:H/Cu films were characterized by transmission electron microscopy to analyze surface morphology. FEMs were constructed using a computer-aided reverse design system, and the effects of antibacterial nanostructured composite films in the stress field were investigated. The maximum stress in the vascular stent occurred at the intersections of net-like structures. Data analysis indicated that the stress decreased by 15% in vascular stents with antibacterial nanostructured composite films compared to the control group, and the stress decreased with increasing film thickness. The present results confirmed that antibacterial nanostructured composite films improve the biomechanical properties of vascular stents and release abnormal stress to prevent restenosis. The results of the present study offer the clinical benefit of inducing superior biomechanical behavior in vascular stents.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalJournal of Biomedical Materials Research - Part A
Volume103
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Stents
Hemodynamics
Composite films
Blood Vessels
Computer-Aided Design
Diamond
Blood Flow Velocity
Transmission Electron Microscopy
Angiography
Flow velocity
Carbon
Arteries
Surface morphology
Film thickness
Diamonds
Blood
Control Groups
Transmission electron microscopy
Research
Chemical analysis

Keywords

  • 3D-reversed model
  • biomechanics
  • finite element analysis
  • surface treatment
  • vascular stent

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys
  • Medicine(all)

Cite this

Effects of antibacterial nanostructured composite films on vascular stents : Hemodynamic behaviors, microstructural characteristics, and biomechanical properties. / Cheng, Han Yi; Hsiao, Wen Tien; Lin, Li Hsiang; Hsu, Ya Ju; Sinrang, Andi Wardihan; Ou, Keng Liang.

In: Journal of Biomedical Materials Research - Part A, Vol. 103, No. 1, 01.01.2015, p. 269-275.

Research output: Contribution to journalArticle

Cheng, Han Yi ; Hsiao, Wen Tien ; Lin, Li Hsiang ; Hsu, Ya Ju ; Sinrang, Andi Wardihan ; Ou, Keng Liang. / Effects of antibacterial nanostructured composite films on vascular stents : Hemodynamic behaviors, microstructural characteristics, and biomechanical properties. In: Journal of Biomedical Materials Research - Part A. 2015 ; Vol. 103, No. 1. pp. 269-275.
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