Effects of anti-hypertensive monotherapy with either calcium channel blocker or angiotensin receptor blocker on arterial stiffness, central hemodynamics, and ventriculo-arterial coupling in uncomplicated hypertension patients

Heng Hsu Lin, Chia Sung Wang, Jiunn-Lee Lin, Juey Jen Hwang, Lian Yu Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: This study is designed to investigate the effects of anti-hypertensive monotherapy [either calcium channel blocker (CCB) or angiotensin receptor blocker (ARB)] on pulsatile hemodynamic parameters in patients with uncomplicated hypertension. Methods: This is a longitudinal observational study. For simplicity, we included patients with uncomplicated hypertension who receivedmono anti-hypertensive therapy with ARB or CCB. Hemodynamic parameters including central arterial pressure (CAP), aortic characteristic impedance (Zc), augmentation index (AI), brachial-ankle pulse wave velocity (baPWV), heart-ankle pulse wave velocity (haPWV), cardiac ultrasonographic parameters and ventriculo-arterial (VA) coupling were measured before, 1 month and 3 months after treatment. Results: A total of 74 subjects were included in our study for analysis from 2007-2008. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and central systolic arterial pressure (CSAP) were significantly reduced 1 and 3 months after initiation of therapy. Among the pulsatile hemodynamic parameters, only the baPWV was significantly reduced (from1537.78±200.63 cm/s to 1460.06±186.09 cm/s to 1456.53±196.03 cm/s, p for trend = 0.016). The haPWV only decreased with borderline significance (from 1015.38±124.26 cm/s to 978.88±126.55 cm/s to 967.99±103.37 cm/s, p for trend = 0.041). The other pulsatile hemodynamic parameters remained unchanged before and after therapy. Subgroup analysis (age above or below52 years) showed that the baPWVwas significantly reduced only in the younger group. Conclusions: Among the pulsatile hemodynamic parameters, only the baPWV was effectively reduced by either CCB or ARB. The improvement of PWV was more evident in younger subjects.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalActa Cardiologica Sinica
Volume29
Issue number1
Publication statusPublished - Jan 1 2013
Externally publishedYes

Keywords

  • Arterial stiffness
  • Central arterial pressure
  • Hypertension
  • Pulse wave velocity
  • Ventriculo-arterial coupling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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