Effects of anti-hypertensive monotherapy with either calcium channel blocker or angiotensin receptor blocker on arterial stiffness, central hemodynamics, and ventriculo-arterial coupling in uncomplicated hypertension patients

Heng Hsu Lin, Chia Sung Wang, Jiunn-Lee Lin, Juey Jen Hwang, Lian Yu Lin

Research output: Contribution to journalArticle

Abstract

Objectives: This study is designed to investigate the effects of anti-hypertensive monotherapy [either calcium channel blocker (CCB) or angiotensin receptor blocker (ARB)] on pulsatile hemodynamic parameters in patients with uncomplicated hypertension. Methods: This is a longitudinal observational study. For simplicity, we included patients with uncomplicated hypertension who receivedmono anti-hypertensive therapy with ARB or CCB. Hemodynamic parameters including central arterial pressure (CAP), aortic characteristic impedance (Zc), augmentation index (AI), brachial-ankle pulse wave velocity (baPWV), heart-ankle pulse wave velocity (haPWV), cardiac ultrasonographic parameters and ventriculo-arterial (VA) coupling were measured before, 1 month and 3 months after treatment. Results: A total of 74 subjects were included in our study for analysis from 2007-2008. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and central systolic arterial pressure (CSAP) were significantly reduced 1 and 3 months after initiation of therapy. Among the pulsatile hemodynamic parameters, only the baPWV was significantly reduced (from1537.78±200.63 cm/s to 1460.06±186.09 cm/s to 1456.53±196.03 cm/s, p for trend = 0.016). The haPWV only decreased with borderline significance (from 1015.38±124.26 cm/s to 978.88±126.55 cm/s to 967.99±103.37 cm/s, p for trend = 0.041). The other pulsatile hemodynamic parameters remained unchanged before and after therapy. Subgroup analysis (age above or below52 years) showed that the baPWVwas significantly reduced only in the younger group. Conclusions: Among the pulsatile hemodynamic parameters, only the baPWV was effectively reduced by either CCB or ARB. The improvement of PWV was more evident in younger subjects.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalActa Cardiologica Sinica
Volume29
Issue number1
Publication statusPublished - Jan 1 2013
Externally publishedYes

Fingerprint

Pulse Wave Analysis
Vascular Stiffness
Angiotensin Receptor Antagonists
Calcium Channels
Antihypertensive Agents
Ankle
Hemodynamics
Blood Pressure
Hypertension
Arterial Pressure
Arm
Ankle Brachial Index
Calcium Channel Blockers
Therapeutics
Electric Impedance
Observational Studies
Longitudinal Studies

Keywords

  • Arterial stiffness
  • Central arterial pressure
  • Hypertension
  • Pulse wave velocity
  • Ventriculo-arterial coupling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Effects of anti-hypertensive monotherapy with either calcium channel blocker or angiotensin receptor blocker on arterial stiffness, central hemodynamics, and ventriculo-arterial coupling in uncomplicated hypertension patients",
abstract = "Objectives: This study is designed to investigate the effects of anti-hypertensive monotherapy [either calcium channel blocker (CCB) or angiotensin receptor blocker (ARB)] on pulsatile hemodynamic parameters in patients with uncomplicated hypertension. Methods: This is a longitudinal observational study. For simplicity, we included patients with uncomplicated hypertension who receivedmono anti-hypertensive therapy with ARB or CCB. Hemodynamic parameters including central arterial pressure (CAP), aortic characteristic impedance (Zc), augmentation index (AI), brachial-ankle pulse wave velocity (baPWV), heart-ankle pulse wave velocity (haPWV), cardiac ultrasonographic parameters and ventriculo-arterial (VA) coupling were measured before, 1 month and 3 months after treatment. Results: A total of 74 subjects were included in our study for analysis from 2007-2008. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and central systolic arterial pressure (CSAP) were significantly reduced 1 and 3 months after initiation of therapy. Among the pulsatile hemodynamic parameters, only the baPWV was significantly reduced (from1537.78±200.63 cm/s to 1460.06±186.09 cm/s to 1456.53±196.03 cm/s, p for trend = 0.016). The haPWV only decreased with borderline significance (from 1015.38±124.26 cm/s to 978.88±126.55 cm/s to 967.99±103.37 cm/s, p for trend = 0.041). The other pulsatile hemodynamic parameters remained unchanged before and after therapy. Subgroup analysis (age above or below52 years) showed that the baPWVwas significantly reduced only in the younger group. Conclusions: Among the pulsatile hemodynamic parameters, only the baPWV was effectively reduced by either CCB or ARB. The improvement of PWV was more evident in younger subjects.",
keywords = "Arterial stiffness, Central arterial pressure, Hypertension, Pulse wave velocity, Ventriculo-arterial coupling",
author = "Lin, {Heng Hsu} and Wang, {Chia Sung} and Jiunn-Lee Lin and Hwang, {Juey Jen} and Lin, {Lian Yu}",
year = "2013",
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day = "1",
language = "English",
volume = "29",
pages = "19--27",
journal = "Acta Cardiologica Sinica",
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TY - JOUR

T1 - Effects of anti-hypertensive monotherapy with either calcium channel blocker or angiotensin receptor blocker on arterial stiffness, central hemodynamics, and ventriculo-arterial coupling in uncomplicated hypertension patients

AU - Lin, Heng Hsu

AU - Wang, Chia Sung

AU - Lin, Jiunn-Lee

AU - Hwang, Juey Jen

AU - Lin, Lian Yu

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objectives: This study is designed to investigate the effects of anti-hypertensive monotherapy [either calcium channel blocker (CCB) or angiotensin receptor blocker (ARB)] on pulsatile hemodynamic parameters in patients with uncomplicated hypertension. Methods: This is a longitudinal observational study. For simplicity, we included patients with uncomplicated hypertension who receivedmono anti-hypertensive therapy with ARB or CCB. Hemodynamic parameters including central arterial pressure (CAP), aortic characteristic impedance (Zc), augmentation index (AI), brachial-ankle pulse wave velocity (baPWV), heart-ankle pulse wave velocity (haPWV), cardiac ultrasonographic parameters and ventriculo-arterial (VA) coupling were measured before, 1 month and 3 months after treatment. Results: A total of 74 subjects were included in our study for analysis from 2007-2008. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and central systolic arterial pressure (CSAP) were significantly reduced 1 and 3 months after initiation of therapy. Among the pulsatile hemodynamic parameters, only the baPWV was significantly reduced (from1537.78±200.63 cm/s to 1460.06±186.09 cm/s to 1456.53±196.03 cm/s, p for trend = 0.016). The haPWV only decreased with borderline significance (from 1015.38±124.26 cm/s to 978.88±126.55 cm/s to 967.99±103.37 cm/s, p for trend = 0.041). The other pulsatile hemodynamic parameters remained unchanged before and after therapy. Subgroup analysis (age above or below52 years) showed that the baPWVwas significantly reduced only in the younger group. Conclusions: Among the pulsatile hemodynamic parameters, only the baPWV was effectively reduced by either CCB or ARB. The improvement of PWV was more evident in younger subjects.

AB - Objectives: This study is designed to investigate the effects of anti-hypertensive monotherapy [either calcium channel blocker (CCB) or angiotensin receptor blocker (ARB)] on pulsatile hemodynamic parameters in patients with uncomplicated hypertension. Methods: This is a longitudinal observational study. For simplicity, we included patients with uncomplicated hypertension who receivedmono anti-hypertensive therapy with ARB or CCB. Hemodynamic parameters including central arterial pressure (CAP), aortic characteristic impedance (Zc), augmentation index (AI), brachial-ankle pulse wave velocity (baPWV), heart-ankle pulse wave velocity (haPWV), cardiac ultrasonographic parameters and ventriculo-arterial (VA) coupling were measured before, 1 month and 3 months after treatment. Results: A total of 74 subjects were included in our study for analysis from 2007-2008. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and central systolic arterial pressure (CSAP) were significantly reduced 1 and 3 months after initiation of therapy. Among the pulsatile hemodynamic parameters, only the baPWV was significantly reduced (from1537.78±200.63 cm/s to 1460.06±186.09 cm/s to 1456.53±196.03 cm/s, p for trend = 0.016). The haPWV only decreased with borderline significance (from 1015.38±124.26 cm/s to 978.88±126.55 cm/s to 967.99±103.37 cm/s, p for trend = 0.041). The other pulsatile hemodynamic parameters remained unchanged before and after therapy. Subgroup analysis (age above or below52 years) showed that the baPWVwas significantly reduced only in the younger group. Conclusions: Among the pulsatile hemodynamic parameters, only the baPWV was effectively reduced by either CCB or ARB. The improvement of PWV was more evident in younger subjects.

KW - Arterial stiffness

KW - Central arterial pressure

KW - Hypertension

KW - Pulse wave velocity

KW - Ventriculo-arterial coupling

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