Effects of amphetamine on human nasal mucosa

H. W. Wang, S. H. Wang, J. Y. Wang, W. Y. Su

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present study was devised to determine the effects of amphetamine on the sympathetic function of human nasal mucosa. A tissue bath method was employed on the vitro preparations of nasal turbinate mucosa from adult patients with nasal allergies or hypertrophic rhinitis. The effects of amphetamine on the contractile response of isolated human nasal mucosal blood vessels were investigated following electrical field stimulation and methoxamine. The results showed that amphetamine inhibited field stimulation and antagonized the effects on mucosal contraction induced by methoxamine. Likewise, the drug increased mucosal basal tension but had local drug toxicity when a 10-4 M solution was used. Amphetamine could potentiate mucosal contraction induced by norepinephrine or epinephrine. The study indicated that amphetamine may increase sympathetic function by potentiating the effect of norepinephrine and that high concentrations of amphetamine may actually antagonize α-adrenoceptors.

Original languageEnglish
Pages (from-to)498-500
Number of pages3
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume253
Issue number8
Publication statusPublished - 1996
Externally publishedYes

    Fingerprint

Keywords

  • Amphetamine
  • Nasal mucosa
  • Sympathetic function

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this