Effects of adlay bran and its ethanolic extract and residue on preneoplastic lesions of the colon in rats

Sing Chung Li, Chiao-Ming Chen, Shu Hui Lin, Wenchang Chiang, Chun Kuang Shih

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

BACKGROUND: Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf) is a cereal crop used in traditional Chinese medicine and as a nutritious food. Epidemiologists have suspected that the low cancer rates in southeastern China might be related to adlay. Previous studies have shown that adlay has anti-tumour and anti-inflammatory activity. This study investigated the effect of adlay bran and its fractions on chemically induced colon carcinogenesis in rats. RESULTS: Adlay bran and its ethanolic extract and residue significantly reduced the number of preneoplastic aberrant crypt foci (ACF) and modified their mucin composition. The inhibitory effect of adlay bran ethanolic extract on ACF showed a dose dependence. Adlay bran and its ethanolic extract suppressed small ACF (one, two or three crypts) and ACF in the distal colon, while the residue suppressed large ACF (four or more crypts). CONCLUSION: These findings suggest the possibility that adlay bran and its ethanolic extract and residue inhibit colonic preneoplastic lesions in an early stage. Adlay and its fractions may have the potential to be developed as chemopreventive cereal products.

Original languageEnglish
Pages (from-to)547-552
Number of pages6
JournalJournal of the Science of Food and Agriculture
Volume91
Issue number3
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Coix lacryma-jobi
Aberrant Crypt Foci
lesions (plant)
bran
colon
Colon
rats
extracts
Coix
Chinese Traditional Medicine
Mucins
China
Neoplasms
Carcinogenesis
Anti-Inflammatory Agents
Food
neoplasms
grain products
mucins
grain crops

Keywords

  • Aberrant crypt foci
  • Adlay bran
  • Colon cancer
  • Mucin

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Food Science
  • Nutrition and Dietetics
  • Biotechnology

Cite this

Effects of adlay bran and its ethanolic extract and residue on preneoplastic lesions of the colon in rats. / Li, Sing Chung; Chen, Chiao-Ming; Lin, Shu Hui; Chiang, Wenchang; Shih, Chun Kuang.

In: Journal of the Science of Food and Agriculture, Vol. 91, No. 3, 02.2011, p. 547-552.

Research output: Contribution to journalArticle

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