Effects of acute exercise on the biosynthesis of eicosanoids in rats.

H. I. Chen, C. J. Jen, W. C. Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We conducted this study to evaluate the effects of different intensities of acute exercise on the regulation of endogenous eicosanoid levels in male Wistar rats. The animals were divided into 4 groups; i.e.: control, mild exercise, moderate exercise and severe exercise. Immediately after exercise, animals were sacrificed. Plasma prostacyclin (PGI2) level and PGI2 release from two vessel segments (i.e., thoracic aorta and inferior vena cava) were determined by a specific 6-keto-PGF1 alpha (125I) radioimmunoassay. Urine thromboxane was determined by a specific 11-dehydro-TXB2 (125I) radioimmunoassay and normalized by urine creatinine. Although both plasma PGI2 and urine thromboxane tended to be elevated by severe exercise, only the increase in thromboxane was statistically significant (p <0.05). In addition, PGI2 release from both vessels were not affected by different intensities of acute exercise. We also observed that aortic PGI2 release was greater than their corresponding veins in each group. We therefore conclude that only severe acute exercise, rather than mild or moderate exercise, may affect prostacyclin-thromboxane balance in rats.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalChinese Journal of Physiology
Volume35
Issue number3
Publication statusPublished - 1992
Externally publishedYes

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Eicosanoids
Epoprostenol
Exercise
Thromboxanes
Urine
Radioimmunoassay
6-Ketoprostaglandin F1 alpha
Inferior Vena Cava
Thoracic Aorta
Wistar Rats
Veins
Creatinine

ASJC Scopus subject areas

  • Physiology

Cite this

Effects of acute exercise on the biosynthesis of eicosanoids in rats. / Chen, H. I.; Jen, C. J.; Chang, W. C.

In: Chinese Journal of Physiology, Vol. 35, No. 3, 1992, p. 197-204.

Research output: Contribution to journalArticle

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