單次甜菜鹼增補對力竭性耐力運動後細胞凋亡、氧化壓力及有氧能力的影響

Translated title of the contribution: Effects of Acute Betaine Supplementation on Apoptosis, Oxidative Stress and Aerobic Capacity After Exhaustive Endurance Exercise

楊明達, 林書丞, 簡鸝慧, 詹貴惠

Research output: Contribution to journalArticle

Abstract

The purpose of this study was to investigate the effects of acute betaine supplementation on apoptosis, oxidative stress and aerobic capacity after exhaustive endurance exercise. In a double-blind, crossover and counterbalanced study, ten healthy men were recruited and performed an exhaustive exercise test with 80% VO_(2max) after 1 hour of the supplementation of betaine (1.25 g of betaine mixed in 300 ml of sport beverage) and placebo (only sport beverage). The average heart rate, maximal heart rate, running time to exhaustion and peak oxygen uptake were recorded during the exercise period. Venous blood samples were drawn before, immediately after and 3 hours after exercise to determine the phenomenons of apoptosis and mitochondrial transmembrane potential decline (MTP decline) of lymphocytes, as well as the concentrations of thiobarbituric acid reactive substance (TBARS) and protein carbonyl (PC). The results indicated that the phenomenon of apoptotic lymphocytes in participants with placebo supplementation at immediately after and 3 hours after exercise was significantly higher than before exercise. However, the apoptotic lymphocytes at 3 hours after exercise was significantly higher than before exercise in betaine supplementation. Moreover, the phenomenon in participants with betaine supplementation at immediately after and 3 hours after exercise were significantly lower than with placebo supplementation. There were no significant differences in other variables between supplementations. Our findings conclude that acute betaine supplementation can effectively attenuate the phenomenon of apoptotic lymphocytes after exhaustive endurance exercise. However, betaine supplementation had no benefits on MTP decline, oxidative stress and aerobic capacity.
Translated title of the contributionEffects of Acute Betaine Supplementation on Apoptosis, Oxidative Stress and Aerobic Capacity After Exhaustive Endurance Exercise
Original languageTraditional Chinese
Pages (from-to)373-383
Number of pages11
Journal大專體育學刊
Volume20
Issue number4
DOIs
Publication statusPublished - Dec 2018

Keywords

  • mitochondrial transmembrane potential
  • thiobarbituric acid reactive substance
  • protein carbonyl
  • running time to exhaustion
  • peak oxygen uptake

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