Effects of a calcineurin inhibitor, tacrolimus, on glutamate-dependent potentiation in pelvic-urethral reflex in anesthetized rats

K. J. Chen, L. W. Chen, J. M. Liao, C. H. Chen, Y. C. Ho, Y. C. Ho, C. L. Cheng, J. J. Lin, P. C. Huang, T. B. Lin

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Abstract

Effects of tacrolimus, a protein phosphatase 2B inhibitor, on the reflex plasticity between the pelvic afferent nerve fibers and the urethra were examined in urethane-anesthetized rats. Repetitive stimulation (1Hz) induced a potentiation (0.9±0.2 and 10.5±1.6 spikes in control and repetitive stimulation groups, respectively, P

Original languageEnglish
Pages (from-to)69-76
Number of pages8
JournalNeuroscience
Volume138
Issue number1
DOIs
Publication statusPublished - 2006
Externally publishedYes

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Keywords

  • External urethral sphincter
  • Micturition
  • N-methyl-D-aspartic acid (NMDA)
  • Pelvic afferent nerve
  • Potentiation
  • Reflex plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chen, K. J., Chen, L. W., Liao, J. M., Chen, C. H., Ho, Y. C., Ho, Y. C., Cheng, C. L., Lin, J. J., Huang, P. C., & Lin, T. B. (2006). Effects of a calcineurin inhibitor, tacrolimus, on glutamate-dependent potentiation in pelvic-urethral reflex in anesthetized rats. Neuroscience, 138(1), 69-76. https://doi.org/10.1016/j.neuroscience.2005.10.059