Effects of a calcineurin inhibitor, tacrolimus, on glutamate-dependent potentiation in pelvic-urethral reflex in anesthetized rats

K. J. Chen; L. W. Chen; J. M. Liao; C. H. Chen; Y. C. Ho; Y. C. Ho; C. L. Cheng; J. J. Lin; P. C. Huang; T. B. Lin

doi:10.1016/j.neuroscience.2005.10.059

Effects of a calcineurin inhibitor, tacrolimus, on glutamate-dependent potentiation in pelvic-urethral reflex in anesthetized rats

K. J. Chen, L. W. Chen, J. M. Liao, C. H. Chen, Y. C. Ho, Y. C. Ho, C. L. Cheng, J. J. Lin, P. C. Huang, T. B. Lin

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

Effects of tacrolimus, a protein phosphatase 2B inhibitor, on the reflex plasticity between the pelvic afferent nerve fibers and the urethra were examined in urethane-anesthetized rats. Repetitive stimulation (1Hz) induced a potentiation (0.9±0.2 and 10.5±1.6 spikes in control and repetitive stimulation groups, respectively, P

Original language	English
Pages (from-to)	69-76
Number of pages	8
Journal	Neuroscience
Volume	138
Issue number	1
DOIs	https://doi.org/10.1016/j.neuroscience.2005.10.059
Publication status	Published - 2006
Externally published	Yes

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Keywords

External urethral sphincter
Micturition
N-methyl-D-aspartic acid (NMDA)
Pelvic afferent nerve
Potentiation
Reflex plasticity

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Chen, K. J., Chen, L. W., Liao, J. M., Chen, C. H., Ho, Y. C., Ho, Y. C., Cheng, C. L., Lin, J. J., Huang, P. C., & Lin, T. B. (2006). Effects of a calcineurin inhibitor, tacrolimus, on glutamate-dependent potentiation in pelvic-urethral reflex in anesthetized rats. Neuroscience, 138(1), 69-76. https://doi.org/10.1016/j.neuroscience.2005.10.059

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AU - Chen, K. J.

AU - Chen, L. W.

AU - Liao, J. M.

AU - Chen, C. H.

AU - Ho, Y. C.

AU - Cheng, C. L.

AU - Lin, J. J.

AU - Huang, P. C.

AU - Lin, T. B.

PY - 2006

Y1 - 2006

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KW - External urethral sphincter

KW - Micturition

KW - N-methyl-D-aspartic acid (NMDA)

KW - Pelvic afferent nerve

KW - Potentiation

KW - Reflex plasticity

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10.1016/j.neuroscience.2005.10.059