Effects of 6-Gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells

Ching Chiung Wang, Lih Geeng Chen, Lain Tze Lee, Ling-Ling Yang

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

6-Gingerol, a naturally occurring plant phenol, is one of the major components of fresh ginger. In this paper, the antioxidative effects of 6-gingerol were detected by DPPH and DCFH assays and, as predicted, 6-gingerol as an antioxidant was shown to protect HL-60 cells from oxidative stress. Moreover, it induced cell death in promyelocytic leukemia HL-60 cells, caused DNA fragmentation and inhibited Bcl-2 expression in HL-60 cells. These results suggested that the inhibition of Bcl-2 expression in HL-60 cells might account for the mechanism of 6-gingerol-induced apoptosis. In the inhibitory assay, the cytotoxic effect of 6-gingerol could be prevented by catalase. We suggest that 6-gingerol induced cell death by mediating reactive oxygen species such as hydrogen peroxide and the superoxide union. Therefore, the results showed that 6-gingerol induced apoptosis in HL-60 cells, not due to its antioxidative activity.

Original languageEnglish
Pages (from-to)641-645
Number of pages5
JournalIn Vivo
Volume17
Issue number6
Publication statusPublished - Nov 2003

Keywords

  • 6-Gingerol
  • Antioxidant
  • Apoptosis
  • Ginger
  • Zingiber officinale
  • Zingiberaceae

ASJC Scopus subject areas

  • Medicine(all)

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