Effects of 3-day IV pantoprazole versus omeprazole on 24-hour intragastric acidity at 3 days in Chinese patients with duodenal ulcer

A single-center, prospective, randomized, comparative, pilot trial

Hwai Jeng Lin, Wen Ching Lo, Yang Chih Cheng, Chin Lin Perng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Pantoprazole and omeprazole are irreversible proton pump inhibitors that have been found to significantly reduce intragastric acidity in patients with peptic ulcer and/or esophagins. It has been reported that gastric acid secretion is lower in the Chinese patients compared with the Western population. Based on a MEDLINE search, no studies of the treatment of in tragastric acidity with IV pantoprazole have been conducted in the Chinese population to date. Objective: This trial was performed to compare the effects of IV pantoprazole versus omeprazole on 24-hour intragastric acidity in Chinese patients with endoscopically confirmed duodenal ulcer. Methods: This single-center, randomized, pilot study was conducted at the Division of Gastroenterology, Department of Medicine, Veterans General Hospital, Taipei, Taiwan. Chinese patients aged 18 to 80 years with endoscopically confirmed duodenal ulcer were randomly assigned to receive a continuous IV infusion of pantoprazole or omeprazole 160 mg/d for 3 days. On days 4 to 14, patients received pantoprazole 40 mg/d or omeprazole 20 mg/d orally. During endoscopic examination at enrollment, an antral biopsy specimen was obtained for rapid urease test, with each patient's agreement, by a blinded investigator. The primary end point was 24-hour intragastric pH on day 3. Secondary end points were percentage of the total time during the 24-hour period (%t) pH

Original languageEnglish
Pages (from-to)1303-1307
Number of pages5
JournalClinical Therapeutics
Volume28
Issue number9
DOIs
Publication statusPublished - Sep 2006
Externally publishedYes

Fingerprint

Omeprazole
Duodenal Ulcer
Veterans Hospitals
Urease
Proton Pump Inhibitors
Gastric Acid
Gastroenterology
Peptic Ulcer
Taiwan
MEDLINE
General Hospitals
Population
pantoprazole
Research Personnel
Medicine
Biopsy

Keywords

  • omeprazole
  • pantoprazole
  • pH, duodenal ulcer

ASJC Scopus subject areas

  • Pharmacology

Cite this

@article{a201c63819d34845a22f0073bc0aa974,
title = "Effects of 3-day IV pantoprazole versus omeprazole on 24-hour intragastric acidity at 3 days in Chinese patients with duodenal ulcer: A single-center, prospective, randomized, comparative, pilot trial",
abstract = "Background: Pantoprazole and omeprazole are irreversible proton pump inhibitors that have been found to significantly reduce intragastric acidity in patients with peptic ulcer and/or esophagins. It has been reported that gastric acid secretion is lower in the Chinese patients compared with the Western population. Based on a MEDLINE search, no studies of the treatment of in tragastric acidity with IV pantoprazole have been conducted in the Chinese population to date. Objective: This trial was performed to compare the effects of IV pantoprazole versus omeprazole on 24-hour intragastric acidity in Chinese patients with endoscopically confirmed duodenal ulcer. Methods: This single-center, randomized, pilot study was conducted at the Division of Gastroenterology, Department of Medicine, Veterans General Hospital, Taipei, Taiwan. Chinese patients aged 18 to 80 years with endoscopically confirmed duodenal ulcer were randomly assigned to receive a continuous IV infusion of pantoprazole or omeprazole 160 mg/d for 3 days. On days 4 to 14, patients received pantoprazole 40 mg/d or omeprazole 20 mg/d orally. During endoscopic examination at enrollment, an antral biopsy specimen was obtained for rapid urease test, with each patient's agreement, by a blinded investigator. The primary end point was 24-hour intragastric pH on day 3. Secondary end points were percentage of the total time during the 24-hour period ({\%}t) pH",
keywords = "omeprazole, pantoprazole, pH, duodenal ulcer",
author = "Lin, {Hwai Jeng} and Lo, {Wen Ching} and Cheng, {Yang Chih} and Perng, {Chin Lin}",
year = "2006",
month = "9",
doi = "10.1016/j.clinthera.2006.09.001",
language = "English",
volume = "28",
pages = "1303--1307",
journal = "Clinical Therapeutics",
issn = "0149-2918",
publisher = "Excerpta Medica",
number = "9",

}

TY - JOUR

T1 - Effects of 3-day IV pantoprazole versus omeprazole on 24-hour intragastric acidity at 3 days in Chinese patients with duodenal ulcer

T2 - A single-center, prospective, randomized, comparative, pilot trial

AU - Lin, Hwai Jeng

AU - Lo, Wen Ching

AU - Cheng, Yang Chih

AU - Perng, Chin Lin

PY - 2006/9

Y1 - 2006/9

N2 - Background: Pantoprazole and omeprazole are irreversible proton pump inhibitors that have been found to significantly reduce intragastric acidity in patients with peptic ulcer and/or esophagins. It has been reported that gastric acid secretion is lower in the Chinese patients compared with the Western population. Based on a MEDLINE search, no studies of the treatment of in tragastric acidity with IV pantoprazole have been conducted in the Chinese population to date. Objective: This trial was performed to compare the effects of IV pantoprazole versus omeprazole on 24-hour intragastric acidity in Chinese patients with endoscopically confirmed duodenal ulcer. Methods: This single-center, randomized, pilot study was conducted at the Division of Gastroenterology, Department of Medicine, Veterans General Hospital, Taipei, Taiwan. Chinese patients aged 18 to 80 years with endoscopically confirmed duodenal ulcer were randomly assigned to receive a continuous IV infusion of pantoprazole or omeprazole 160 mg/d for 3 days. On days 4 to 14, patients received pantoprazole 40 mg/d or omeprazole 20 mg/d orally. During endoscopic examination at enrollment, an antral biopsy specimen was obtained for rapid urease test, with each patient's agreement, by a blinded investigator. The primary end point was 24-hour intragastric pH on day 3. Secondary end points were percentage of the total time during the 24-hour period (%t) pH

AB - Background: Pantoprazole and omeprazole are irreversible proton pump inhibitors that have been found to significantly reduce intragastric acidity in patients with peptic ulcer and/or esophagins. It has been reported that gastric acid secretion is lower in the Chinese patients compared with the Western population. Based on a MEDLINE search, no studies of the treatment of in tragastric acidity with IV pantoprazole have been conducted in the Chinese population to date. Objective: This trial was performed to compare the effects of IV pantoprazole versus omeprazole on 24-hour intragastric acidity in Chinese patients with endoscopically confirmed duodenal ulcer. Methods: This single-center, randomized, pilot study was conducted at the Division of Gastroenterology, Department of Medicine, Veterans General Hospital, Taipei, Taiwan. Chinese patients aged 18 to 80 years with endoscopically confirmed duodenal ulcer were randomly assigned to receive a continuous IV infusion of pantoprazole or omeprazole 160 mg/d for 3 days. On days 4 to 14, patients received pantoprazole 40 mg/d or omeprazole 20 mg/d orally. During endoscopic examination at enrollment, an antral biopsy specimen was obtained for rapid urease test, with each patient's agreement, by a blinded investigator. The primary end point was 24-hour intragastric pH on day 3. Secondary end points were percentage of the total time during the 24-hour period (%t) pH

KW - omeprazole

KW - pantoprazole

KW - pH, duodenal ulcer

UR - http://www.scopus.com/inward/record.url?scp=33750052574&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750052574&partnerID=8YFLogxK

U2 - 10.1016/j.clinthera.2006.09.001

DO - 10.1016/j.clinthera.2006.09.001

M3 - Article

VL - 28

SP - 1303

EP - 1307

JO - Clinical Therapeutics

JF - Clinical Therapeutics

SN - 0149-2918

IS - 9

ER -